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Peptide record

TPDB15431

Antibacterial Antifungal Toxicity standard
40 amino acids
Basic Information
3D PDB MODEL
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TPDB15431
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia CAFPdb
standard
No
A 40-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, and CAFPdb, with an available 3D structural model.
Sequence
ATCDLLSPFKVGHAACALHCIALGRRGGWCDGRAVCNCRR
Physicochemical Analysis
C178H290N62O48S6
EQMY
AC
4259.01
8.60
8
2
15
+4
2.76
0.185
78.25
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5875
137.94
9
Residue Composition
number
6
A
5
R
1
N
2
D
6
C
0
E
0
Q
5
G
2
H
1
I
4
L
1
K
0
M
1
F
1
P
1
S
1
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 6 R: 5 N: 1 D: 2 C: 6 E: 0 Q: 0 G: 5 H: 2 I: 1 L: 4 K: 1 M: 0 F: 1 P: 1 S: 1 T: 1 W: 1 Y: 0 V: 2
Chemical Descriptors
40
C178H290N62O48S6
4259.01
8.60
+4
2.76
0.185
Evidence Records 15 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.5-8 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Oncocin is particularly active against Gram-negative bacteria E. coli 8 strains (MIC 0.5-8 ug/ml), P. aeruginosa 8 strains (MIC 2-8 ug/ml) and K. pneumoniae 6 strains (MIC 0.25-8 ug/ml),
Evidence 2 Activity

Activity

MIC
Antibacterial
2-8 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP

Other

s particularly active against Gram-negative bacteria E. coli 8 strains (MIC 0.5-8 ug/ml), P. aeruginosa 8 strains (MIC 2-8 ug/ml) and K. pneumoniae 6 strains (MIC 0.25-8 ug/ml), A. baumannii 5 strains (MIC 0.5-2 ug/ml),
Evidence 3 Activity

Activity

MIC
Antibacterial
0.25-8 µg/mL

Target

Klebsiella pneumoniae

Source & Reference

dbAMP

Other

bacteria E. coli 8 strains (MIC 0.5-8 ug/ml), P. aeruginosa 8 strains (MIC 2-8 ug/ml) and K. pneumoniae 6 strains (MIC 0.25-8 ug/ml), A. baumannii 5 strains (MIC 0.5-2 ug/ml), E. cloacae (MIC 0.125-4 ug/ml), P. vulgaris (M
Evidence 4 Activity

Activity

MIC
Antibacterial
0.5-2 µg/mL

Target

A. baumannii

Source & Reference

dbAMP

Other

, P. aeruginosa 8 strains (MIC 2-8 ug/ml) and K. pneumoniae 6 strains (MIC 0.25-8 ug/ml), A. baumannii 5 strains (MIC 0.5-2 ug/ml), E. cloacae (MIC 0.125-4 ug/ml), P. vulgaris (MIC 4 ug/ml), and Stenotrophomonas (MIC 8-3
Evidence 5 Activity

Activity

MIC
Antibacterial
0.125-4 µg/mL

Target

Enterobacter cloacae

Source & Reference

dbAMP

Other

and K. pneumoniae 6 strains (MIC 0.25-8 ug/ml), A. baumannii 5 strains (MIC 0.5-2 ug/ml), E. cloacae (MIC 0.125-4 ug/ml), P. vulgaris (MIC 4 ug/ml), and Stenotrophomonas (MIC 8-32 ug/ml).
Evidence 6 Activity

Activity

MIC
Antibacterial
4 µg/mL

Target

P. vulgaris

Source & Reference

dbAMP

Other

0.25-8 ug/ml), A. baumannii 5 strains (MIC 0.5-2 ug/ml), E. cloacae (MIC 0.125-4 ug/ml), P. vulgaris (MIC 4 ug/ml), and Stenotrophomonas (MIC 8-32 ug/ml).
Evidence 7 Activity

Activity

MIC
Antibacterial
1-8 µM

Target

Staphylococcus aureus ATCC 6538

Source & Reference

dbAMP

Other

Active against S. aureus ATCC 6538 (MIC 1-8 uM), E-coli (MIC>32-64 uM), P-aeruginos (MIC >32-64 uM).
Evidence 8 Activity

Activity

MIC
Antifungal
0.5-8 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Oncocin is particularly active against Gram-negative bacteria E. coli 8 strains (MIC 0.5-8 ug/ml), P. aeruginosa 8 strains (MIC 2-8 ug/ml) and K. pneumoniae 6 strains (MIC 0.25-8 ug/ml),
Evidence 9 Activity

Activity

MIC
Antifungal
2-8 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP CAFPdb

Other

s particularly active against Gram-negative bacteria E. coli 8 strains (MIC 0.5-8 ug/ml), P. aeruginosa 8 strains (MIC 2-8 ug/ml) and K. pneumoniae 6 strains (MIC 0.25-8 ug/ml), A. baumannii 5 strains (MIC 0.5-2 ug/ml),
Evidence 10 Activity

Activity

MIC
Antifungal
0.25-8 µg/mL

Target

Klebsiella pneumoniae

Source & Reference

dbAMP CAFPdb

Other

bacteria E. coli 8 strains (MIC 0.5-8 ug/ml), P. aeruginosa 8 strains (MIC 2-8 ug/ml) and K. pneumoniae 6 strains (MIC 0.25-8 ug/ml), A. baumannii 5 strains (MIC 0.5-2 ug/ml), E. cloacae (MIC 0.125-4 ug/ml), P. vulgaris (M
Evidence 11 Activity

Activity

MIC
Antifungal
0.5-2 µg/mL

Target

A. baumannii

Source & Reference

dbAMP CAFPdb

Other

, P. aeruginosa 8 strains (MIC 2-8 ug/ml) and K. pneumoniae 6 strains (MIC 0.25-8 ug/ml), A. baumannii 5 strains (MIC 0.5-2 ug/ml), E. cloacae (MIC 0.125-4 ug/ml), P. vulgaris (MIC 4 ug/ml), and Stenotrophomonas (MIC 8-3
Evidence 12 Activity

Activity

MIC
Antifungal
0.125-4 µg/mL

Target

Enterobacter cloacae

Source & Reference

dbAMP CAFPdb

Other

and K. pneumoniae 6 strains (MIC 0.25-8 ug/ml), A. baumannii 5 strains (MIC 0.5-2 ug/ml), E. cloacae (MIC 0.125-4 ug/ml), P. vulgaris (MIC 4 ug/ml), and Stenotrophomonas (MIC 8-32 ug/ml).
Evidence 13 Activity

Activity

MIC
Antifungal
4 µg/mL

Target

P. vulgaris

Source & Reference

dbAMP CAFPdb

Other

0.25-8 ug/ml), A. baumannii 5 strains (MIC 0.5-2 ug/ml), E. cloacae (MIC 0.125-4 ug/ml), P. vulgaris (MIC 4 ug/ml), and Stenotrophomonas (MIC 8-32 ug/ml).
Evidence 14 Activity

Activity

MIC
Antifungal
1-8 µM

Target

Staphylococcus aureus ATCC 6538

Source & Reference

dbAMP CAFPdb

Other

Active against S. aureus ATCC 6538 (MIC 1-8 uM), E-coli (MIC>32-64 uM), P-aeruginos (MIC >32-64 uM).
Evidence 15 Activity

Activity

IC50
Toxicity
>64 µM
Cytotoxic
IC50 | >64 | µM | target cell: Human fibroblasts MRC-5 SV2

Target

Human fibroblasts MRC-5 SV2

Source & Reference

NA
DBAASP
In Vitro Evaluation of Antimicrobial Peptides from the Black Soldier Fly (Hermetia Illucens) against a Selection of Human Pathogens. | Microbiol Spectr | 2022