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Peptide record

TPDB15415

Antibacterial Anticancer Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB15415
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
dbAMP Peptipedia ToxinPred 3.0
standard
No
A 26-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
GMFTNMLKGIGKLAGKAALGAVKTLA
Physicochemical Analysis
C115H201N31O30S2
RDCEQHPSWY
AG
2562.17
11.00
4
0
14
+4
-0.21
0.654
105.38
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
5
A
0
R
1
N
0
D
0
C
0
E
0
Q
5
G
0
H
1
I
4
L
4
K
2
M
1
F
0
P
0
S
2
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 5 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 5 H: 0 I: 1 L: 4 K: 4 M: 2 F: 1 P: 0 S: 0 T: 2 W: 0 Y: 0 V: 1
Chemical Descriptors
26
C115H201N31O30S2
2562.17
11.00
+4
-0.21
0.654
Evidence Records 8 records
Evidence 1 Activity

Activity

IC50
Toxicity
8.43 µM
Cytotoxic
IC50 | 8.43 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
In Vitro and In Vivo Studies on the Antibacterial Activity and Safety of a New Antimicrobial Peptide Dermaseptin-AC | Microbiol Spectr | 2021
Evidence 2 Activity

Activity

IC50
Toxicity
18.26 µM
Cytotoxic
IC50 | 18.26 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
In Vitro and In Vivo Studies on the Antibacterial Activity and Safety of a New Antimicrobial Peptide Dermaseptin-AC | Microbiol Spectr | 2021
Evidence 3 Activity

Activity

IC50
Toxicity
18.26 µM
Cytotoxic
IC50 | 18.26 | µM | target cell: Mouse embryonic stem cells C57BL/6J

Target

Mouse embryonic stem cells C57BL/6J

Source & Reference

NA
DBAASP
In Vitro and In Vivo Studies on the Antibacterial Activity and Safety of a New Antimicrobial Peptide Dermaseptin-AC | Microbiol Spectr | 2021
Evidence 4 Activity

Activity

2.73% Hemolysis
Toxicity
2 µM
Hemolytic Cytotoxic
2.73% Hemolysis | 2 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
In Vitro and In Vivo Studies on the Antibacterial Activity and Safety of a New Antimicrobial Peptide Dermaseptin-AC | Microbiol Spectr | 2021
Evidence 5 Activity

Activity

4.31% Hemolysis
Toxicity
4 µM
Hemolytic Cytotoxic
4.31% Hemolysis | 4 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Evidence 6 Activity

Activity

7.47% Hemolysis
Toxicity
8 µM
Hemolytic Cytotoxic
7.47% Hemolysis | 8 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
In Vitro and In Vivo Studies on the Antibacterial Activity and Safety of a New Antimicrobial Peptide Dermaseptin-AC | Microbiol Spectr | 2021
Evidence 7 Activity

Activity

50% Hemolysis
Toxicity
76.55 µM
Hemolytic Cytotoxic
50% Hemolysis | 76.55 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
In Vitro and In Vivo Studies on the Antibacterial Activity and Safety of a New Antimicrobial Peptide Dermaseptin-AC | Microbiol Spectr | 2021
Evidence 8 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Microbiol Spectr. 2021 Dec 22 9(3):e0131821.