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Peptide record

TPDB15413

Antibacterial Anticancer Antifungal Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB15413
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
dbAMP Peptipedia CancerPPD 2.0
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, Peptipedia, and CancerPPD 2.0, with an available 3D structural model.
Sequence
WLWKKIKNVAKAAGKAAKGAL
Physicochemical Analysis
C107H178N30O23
RDCEQHMFPSTY
AK
2252.78
11.21
6
0
12
+6
0.30
-0.114
98.10
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
11000
488.29
1
Residue Composition
number
6
A
0
R
1
N
0
D
0
C
0
E
0
Q
2
G
0
H
1
I
2
L
6
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
1
V
Amino Acid Distribution
A: 6 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 2 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 1
Chemical Descriptors
21
C107H178N30O23
2252.78
11.21
+6
0.30
-0.114
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
Toxicity
293.2 µM
Cytotoxic
IC50 | 293.2 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
Exploration of the Structure-Function Relationships of a Novel Frog Skin Secretion-Derived Bioactive Peptide, t-DPH1, through Use of Rational Design, Cationicity Enhancement and In Vitro Studies | Antibiotics (Basel) | 2021
Evidence 2 Activity

Activity

IC50
Toxicity
119.3 µM
Cytotoxic
IC50 | 119.3 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Exploration of the Structure-Function Relationships of a Novel Frog Skin Secretion-Derived Bioactive Peptide, t-DPH1, through Use of Rational Design, Cationicity Enhancement and In Vitro Studies | Antibiotics (Basel) | 2021
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
2094 µM
Hemolytic Cytotoxic
50% Hemolysis | 2094 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Exploration of the Structure-Function Relationships of a Novel Frog Skin Secretion-Derived Bioactive Peptide, t-DPH1, through Use of Rational Design, Cationicity Enhancement and In Vitro Studies | Antibiotics (Basel) | 2021
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Antibiotics (Basel). 2021 Dec 14 10(12):1533.