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Peptide record

TPDB15413

Antibacterial Anticancer Antifungal Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB15413
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
dbAMP Peptipedia CancerPPD 2.0
standard
No
A 21-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, Peptipedia, and CancerPPD 2.0, with an available 3D structural model.
Sequence
WLWKKIKNVAKAAGKAAKGAL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C107H178N30O23
RDCEQHMFPSTY
AK
2252.78
11.21
6
0
12
+6
0.18
-0.114
98.10
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
11000
4.88
1
Residue Composition
number
6
A
0
R
1
N
0
D
0
C
0
E
0
Q
2
G
0
H
1
I
2
L
6
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
1
V
Amino Acid Distribution
A: 6 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 2 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 1
Chemical Descriptors
21 reviewed residue count
C107H178N30O23 sequence-only estimate (linear, free termini)
2252.78 sequence-only estimate (linear, free termini)
11.21 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
0.18 sequence-only estimate (linear, free termini)
-0.114 sequence-only estimate (linear, free termini)
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
Toxicity
293.2 µM
Cytotoxic
IC50 | 293.2 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
Exploration of the Structure-Function Relationships of a Novel Frog Skin Secretion-Derived Bioactive Peptide, t-DPH1, through Use of Rational Design, Cationicity Enhancement and In Vitro Studies | Antibiotics (Basel) | 2021
Evidence 2 Activity

Activity

IC50
Toxicity
119.3 µM
Cytotoxic
IC50 | 119.3 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Exploration of the Structure-Function Relationships of a Novel Frog Skin Secretion-Derived Bioactive Peptide, t-DPH1, through Use of Rational Design, Cationicity Enhancement and In Vitro Studies | Antibiotics (Basel) | 2021
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
2094 µM
Hemolytic Cytotoxic
50% Hemolysis | 2094 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Exploration of the Structure-Function Relationships of a Novel Frog Skin Secretion-Derived Bioactive Peptide, t-DPH1, through Use of Rational Design, Cationicity Enhancement and In Vitro Studies | Antibiotics (Basel) | 2021
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Antibiotics (Basel). 2021 Dec 14 10(12):1533.