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Peptide record

TPDB15412

Antibacterial Anticancer Antifungal Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB15412
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
dbAMP Peptipedia CancerPPD 2.0
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, Peptipedia, and CancerPPD 2.0, with an available 3D structural model.
Sequence
GLWKKIKNVAKAAGKAAKGAL
Physicochemical Analysis
C98H171N29O23
RDCEQHMFPSTY
AK
2123.62
11.21
6
0
11
+6
2.16
-0.090
98.10
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
258.99
1
Residue Composition
number
6
A
0
R
1
N
0
D
0
C
0
E
0
Q
3
G
0
H
1
I
2
L
6
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 6 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 1 L: 2 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
21
C98H171N29O23
2123.62
11.21
+6
2.16
-0.090
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
Toxicity
340.2 µM
Cytotoxic
IC50 | 340.2 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
Exploration of the Structure-Function Relationships of a Novel Frog Skin Secretion-Derived Bioactive Peptide, t-DPH1, through Use of Rational Design, Cationicity Enhancement and In Vitro Studies | Antibiotics (Basel) | 2021
Evidence 2 Activity

Activity

IC50
Toxicity
151.4 µM
Cytotoxic
IC50 | 151.4 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Exploration of the Structure-Function Relationships of a Novel Frog Skin Secretion-Derived Bioactive Peptide, t-DPH1, through Use of Rational Design, Cationicity Enhancement and In Vitro Studies | Antibiotics (Basel) | 2021
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
834.6 µM
Hemolytic Cytotoxic
50% Hemolysis | 834.6 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Exploration of the Structure-Function Relationships of a Novel Frog Skin Secretion-Derived Bioactive Peptide, t-DPH1, through Use of Rational Design, Cationicity Enhancement and In Vitro Studies | Antibiotics (Basel) | 2021
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Antibiotics (Basel). 2021 Dec 14 10(12):1532.