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Peptide record

TPDB15410

Antibacterial Anticancer Antifungal Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB15410
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
dbAMP Peptipedia CancerPPD 2.0
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, Peptipedia, and CancerPPD 2.0, with an available 3D structural model.
Sequence
GLWKKIKNVAAAAGKAALGAL
Physicochemical Analysis
C95H163N27O23
RDCEQHMFPSTY
A
2051.51
11.00
4
0
13
+4
-0.55
0.548
121.43
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
268.10
1
Residue Composition
number
7
A
0
R
1
N
0
D
0
C
0
E
0
Q
3
G
0
H
1
I
3
L
4
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 7 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 1 L: 3 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
21
C95H163N27O23
2051.51
11.00
+4
-0.55
0.548
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
Toxicity
46.02 µM
Cytotoxic
IC50 | 46.02 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
Exploration of the Structure-Function Relationships of a Novel Frog Skin Secretion-Derived Bioactive Peptide, t-DPH1, through Use of Rational Design, Cationicity Enhancement and In Vitro Studies | Antibiotics (Basel) | 2021
Evidence 2 Activity

Activity

IC50
Toxicity
63.37 µM
Cytotoxic
IC50 | 63.37 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Exploration of the Structure-Function Relationships of a Novel Frog Skin Secretion-Derived Bioactive Peptide, t-DPH1, through Use of Rational Design, Cationicity Enhancement and In Vitro Studies | Antibiotics (Basel) | 2021
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
444.8 µM
Hemolytic Cytotoxic
50% Hemolysis | 444.8 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Exploration of the Structure-Function Relationships of a Novel Frog Skin Secretion-Derived Bioactive Peptide, t-DPH1, through Use of Rational Design, Cationicity Enhancement and In Vitro Studies | Antibiotics (Basel) | 2021
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Antibiotics (Basel). 2021 Dec 14 10(12):1530.