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Peptide record

TPDB15409

Antibacterial Anticancer Antifungal Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB15409
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
dbAMP Peptipedia CancerPPD 2.0 dbACP AFP-GFuse CAFPdb ToxinPred 3.0
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Sequence
GLWSKIKNVAAAAGKAALGAL
Physicochemical Analysis
C92H156N26O24
RDCEQHMFPTY
A
2010.41
10.84
3
0
13
+3
-1.41
0.695
121.43
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
273.58
2
Residue Composition
number
7
A
0
R
1
N
0
D
0
C
0
E
0
Q
3
G
0
H
1
I
3
L
3
K
0
M
0
F
0
P
1
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 7 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 1 L: 3 K: 3 M: 0 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
21
C92H156N26O24
2010.41
10.84
+3
-1.41
0.695
Evidence Records 16 records
Evidence 1 Activity

Activity

MIC
Antibacterial
8-16 µM

Target

Staphylococcus aureus ATCC 6538 or MRSA NCTC 12493

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
inhibits S. aureus ATCC 6538 or MRSA NCTC 12493 (MIC 8-16 uM), E.faecalis NCTC 12697 (MIC 128 uM), E. coli ATCC 8739 (MIC 2 uM), K. pneumoniae ATCC 438
Evidence 2 Activity

Activity

MIC
Antibacterial
128 µM

Target

Enterococcus faecalis NCTC 12697

Source & Reference

dbAMP

Other

inhibits S. aureus ATCC 6538 or MRSA NCTC 12493 (MIC 8-16 uM), E.faecalis NCTC 12697 (MIC 128 uM), E. coli ATCC 8739 (MIC 2 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 90
Evidence 3 Activity

Activity

MIC
Antibacterial
2 µM

Target

Escherichia coli ATCC 8739

Source & Reference

dbAMP

Other

S. aureus ATCC 6538 or MRSA NCTC 12493 (MIC 8-16 uM), E.faecalis NCTC 12697 (MIC 128 uM), E. coli ATCC 8739 (MIC 2 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 9027 (MIC 16 uM), C. albicans AT
Evidence 4 Activity

Activity

MIC
Antibacterial
8 µM

Target

Klebsiella pneumoniae ATCC 43816

Source & Reference

dbAMP

Other

TC 12493 (MIC 8-16 uM), E.faecalis NCTC 12697 (MIC 128 uM), E. coli ATCC 8739 (MIC 2 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 9027 (MIC 16 uM), C. albicans ATCC 10231 (MIC 64 uM). MBCs are simila
Evidence 5 Activity

Activity

MIC
Antibacterial
16 µM

Target

Pseudomonas aeruginosa ATCC 9027

Source & Reference

dbAMP

Other

TC 12697 (MIC 128 uM), E. coli ATCC 8739 (MIC 2 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 9027 (MIC 16 uM), C. albicans ATCC 10231 (MIC 64 uM). MBCs are similar or 2-fold higher. At 2 MIC, the pep
Evidence 6 Activity

Activity

MIC
Antibacterial
64 µM

Target

Candida albicans ATCC 10231

Source & Reference

dbAMP

Other

739 (MIC 2 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 9027 (MIC 16 uM), C. albicans ATCC 10231 (MIC 64 uM). MBCs are similar or 2-fold higher. At 2 MIC, the peptide killed E. coli and S. aureus in
Evidence 7 Activity

Activity

MIC
Antifungal
8-16 µM

Target

Staphylococcus aureus ATCC 6538 or MRSA NCTC 12493

Source & Reference

dbAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
inhibits S. aureus ATCC 6538 or MRSA NCTC 12493 (MIC 8-16 uM), E.faecalis NCTC 12697 (MIC 128 uM), E. coli ATCC 8739 (MIC 2 uM), K. pneumoniae ATCC 438
Evidence 8 Activity

Activity

MIC
Antifungal
128 µM

Target

Enterococcus faecalis NCTC 12697

Source & Reference

dbAMP CAFPdb

Other

inhibits S. aureus ATCC 6538 or MRSA NCTC 12493 (MIC 8-16 uM), E.faecalis NCTC 12697 (MIC 128 uM), E. coli ATCC 8739 (MIC 2 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 90
Evidence 9 Activity

Activity

MIC
Antifungal
2 µM

Target

Escherichia coli ATCC 8739

Source & Reference

dbAMP CAFPdb

Other

S. aureus ATCC 6538 or MRSA NCTC 12493 (MIC 8-16 uM), E.faecalis NCTC 12697 (MIC 128 uM), E. coli ATCC 8739 (MIC 2 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 9027 (MIC 16 uM), C. albicans AT
Evidence 10 Activity

Activity

MIC
Antifungal
8 µM

Target

Klebsiella pneumoniae ATCC 43816

Source & Reference

dbAMP CAFPdb

Other

TC 12493 (MIC 8-16 uM), E.faecalis NCTC 12697 (MIC 128 uM), E. coli ATCC 8739 (MIC 2 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 9027 (MIC 16 uM), C. albicans ATCC 10231 (MIC 64 uM). MBCs are simila
Evidence 11 Activity

Activity

MIC
Antifungal
16 µM

Target

Pseudomonas aeruginosa ATCC 9027

Source & Reference

dbAMP CAFPdb

Other

TC 12697 (MIC 128 uM), E. coli ATCC 8739 (MIC 2 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 9027 (MIC 16 uM), C. albicans ATCC 10231 (MIC 64 uM). MBCs are similar or 2-fold higher. At 2 MIC, the pep
Evidence 12 Activity

Activity

MIC
Antifungal
64 µM

Target

Candida albicans ATCC 10231

Source & Reference

dbAMP CAFPdb

Other

739 (MIC 2 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 9027 (MIC 16 uM), C. albicans ATCC 10231 (MIC 64 uM). MBCs are similar or 2-fold higher. At 2 MIC, the peptide killed E. coli and S. aureus in
Evidence 13 Activity

Activity

IC50
Toxicity
29.85 µM
Cytotoxic
IC50 | 29.85 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
Exploration of the Structure-Function Relationships of a Novel Frog Skin Secretion-Derived Bioactive Peptide, t-DPH1, through Use of Rational Design, Cationicity Enhancement and In Vitro Studies | Antibiotics (Basel) | 2021
Evidence 14 Activity

Activity

IC50
Toxicity
175.6 µM
Cytotoxic
IC50 | 175.6 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Exploration of the Structure-Function Relationships of a Novel Frog Skin Secretion-Derived Bioactive Peptide, t-DPH1, through Use of Rational Design, Cationicity Enhancement and In Vitro Studies | Antibiotics (Basel) | 2021
Evidence 15 Activity

Activity

50% Hemolysis
Toxicity
106.4 µM
Hemolytic Cytotoxic
50% Hemolysis | 106.4 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Exploration of the Structure-Function Relationships of a Novel Frog Skin Secretion-Derived Bioactive Peptide, t-DPH1, through Use of Rational Design, Cationicity Enhancement and In Vitro Studies | Antibiotics (Basel) | 2021
Evidence 16 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Antibiotics (Basel). 2021 Dec 14 10(12):1529.