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Peptide record

TPDB15407

Antibacterial Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB15407
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia
standard
No
A 24-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Sequence
SKEKIGKEFKRIVQRIKDFLRNLV
Physicochemical Analysis
C134H230N40O34
ACHMPTWY
K
2945.55
11.06
8
3
9
+5
9.62
-0.692
105.42
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
0
A
3
R
1
N
1
D
0
C
2
E
1
Q
1
G
0
H
3
I
2
L
5
K
0
M
2
F
0
P
1
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 1 C: 0 E: 2 Q: 1 G: 1 H: 0 I: 3 L: 2 K: 5 M: 0 F: 2 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
24
C134H230N40O34
2945.55
11.06
+5
9.62
-0.692
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2 µM

Target

E. faecium V284-17

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against E. faecium V284-17 (MIC 2 uM), S. aureus USA300 (MIC 4 uM), K-pneumoniae E406-17 (MIC>32 uM). A. baumannii B28-16 (MIC
Evidence 2 Activity

Activity

MIC
Antibacterial
4 µM

Target

Staphylococcus aureus USA300

Source & Reference

dbAMP

Other

Active against E. faecium V284-17 (MIC 2 uM), S. aureus USA300 (MIC 4 uM), K-pneumoniae E406-17 (MIC>32 uM). A. baumannii B28-16 (MIC 4-8 uM), P-aeruginosa E411-17
Evidence 3 Activity

Activity

MIC
Antibacterial
4-8 µM

Target

A. baumannii B28-16

Source & Reference

dbAMP

Other

aecium V284-17 (MIC 2 uM), S. aureus USA300 (MIC 4 uM), K-pneumoniae E406-17 (MIC>32 uM). A. baumannii B28-16 (MIC 4-8 uM), P-aeruginosa E411-17 (MIC > 32 uM), and E. coli E423-17 (MIC 16 uM). It also dispersed p
Evidence 4 Activity

Activity

MIC
Antibacterial
16 µM

Target

Escherichia coli E423-17

Source & Reference

dbAMP

Other

17 (MIC>32 uM). A. baumannii B28-16 (MIC 4-8 uM), P-aeruginosa E411-17 (MIC > 32 uM), and E. coli E423-17 (MIC 16 uM). It also dispersed preformed biofilms of both A. baumannii and S. aureus USA300.
Evidence 5 Activity

Activity

<10% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
<10% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure and Activity of a Selective Antibiofilm Peptide SK-24 Derived from the NMR Structure of Human Cathelicidin LL-37. | Pharmaceuticals (Basel) | 2021
Evidence 6 Activity

Activity

15% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
15% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure and Activity of a Selective Antibiofilm Peptide SK-24 Derived from the NMR Structure of Human Cathelicidin LL-37. | Pharmaceuticals (Basel) | 2021