TPDB

3D PDB MODEL

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TPDB ID TPDB15402

Peptide_Name

B1OS-L

Activity

Antibacterial Anticancer

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

dbAMP CancerPPD 2.0

Sequence_Type

standard

Has_Modification No

Description A 24-aa standard natural multi-activity (Antibacterial and Anticancer) peptide sequence curated from dbAMP and CancerPPD 2.0, with an available 3D structural model.

Sequence

FLPLIASLAGNVVPKIFCKITKRC

FASTA

>TPDB15402|Antibacterial;Anticancer|length=24
FLPLIASLAGNVVPKIFCKITKRC

Formula C123H207N31O28S2

Absent Amino Acids DEQHMWY

Common Amino Acids ILK

Mass 2632.31

PI 10.32

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 12

Net Charge +4

Boman Index -0.17

Hydrophobicity 0.946

Aliphatic Index 130.00

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 125

Absorbance 280nm 4.75

Polar Residues 5

number

2

A

1

R

1

N

0

D

2

C

0

E

0

Q

1

G

0

H

3

I

3

L

3

K

0

M

2

F

2

P

1

S

1

T

0

W

0

Y

2

V

Amino Acid Distribution

A: 2 R: 1 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 3 K: 3 M: 0 F: 2 P: 2 S: 1 T: 1 W: 0 Y: 0 V: 2

Length

24

Formula

C123H207N31O28S2

Mass

2632.31

PI

10.32

Net Charge

+4

Boman Index

-0.17

Hydrophobicity

0.946

C_terminal_Modification

Free

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antimicrobial

Origin

B-1OS

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 3.976 µM

Detail Source Activity Anticancer

Activity Measurement 3.976 µM

Target

Cancer Type Lung Cancer

Cell Line H-838

Tissue Affected Lung

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2021

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 5.473 µM

Detail Source Activity Anticancer

Activity Measurement 5.473 µM

Target

Cancer Type Prostate Cancer

Cell Line PC-3

Tissue Affected Prostate

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2021

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 8.629 µM

Detail Source Activity Anticancer

Activity Measurement 8.629 µM

Target

Cancer Type Brain Tumor

Cell Line U251-MG

Tissue Affected Brain

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2021

Evidence 4 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 8.883 µM

Detail Source Activity Anticancer

Activity Measurement 8.883 µM

Target

Cancer Type Breast Cancer

Cell Line MCF-7

Tissue Affected Breast

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2021

Evidence 5 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 11.03 µM

Detail Source Activity Anticancer

Activity Measurement 11.03 µM

Target

Cancer Type Colon Cancer

Cell Line HCT-116

Tissue Affected Colon

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2021