TPDB

3D PDB MODEL

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TPDB ID TPDB15401

Peptide_Name

B1OS

Activity

Antibacterial Anticancer

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

dbAMP CancerPPD 2.0 dbACP

Sequence_Type

standard

Has_Modification No

Description A 23-aa standard natural multi-activity (Antibacterial and Anticancer) peptide sequence curated from dbAMP, CancerPPD 2.0, and dbACP, with an available 3D structural model.

Sequence

FPLIASLAGNVVPKIFCKITKRC

FASTA

>TPDB15401|Antibacterial;Anticancer|length=23
FPLIASLAGNVVPKIFCKITKRC

Formula C117H196N30O27S2

Absent Amino Acids DEQHMWY

Common Amino Acids IK

Mass 2519.15

PI 10.32

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 11

Net Charge +4

Boman Index 0.39

Hydrophobicity 0.822

Aliphatic Index 118.70

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 125

Absorbance 280nm 4.96

Polar Residues 5

number

2

A

1

R

1

N

0

D

2

C

0

E

0

Q

1

G

0

H

3

I

2

L

3

K

0

M

2

F

2

P

1

S

1

T

0

W

0

Y

2

V

Amino Acid Distribution

A: 2 R: 1 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 2 K: 3 M: 0 F: 2 P: 2 S: 1 T: 1 W: 0 Y: 0 V: 2

Length

23

Formula

C117H196N30O27S2

Mass

2519.15

PI

10.32

Net Charge

+4

Boman Index

0.39

Hydrophobicity

0.822

C_terminal_Modification

Free

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antimicrobial

Origin

Odorrana schmackeri

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 36.84 µM

Detail Source Activity Anticancer

Activity Measurement 36.84 µM

Target

Cancer Type Lung Cancer

Cell Line H-838

Tissue Affected Lung

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2021

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 95.94 µM

Detail Source Activity Anticancer

Activity Measurement 95.94 µM

Target

Cancer Type Prostate Cancer

Cell Line PC-3

Tissue Affected Prostate

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2021

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 233.0 µM

Detail Source Activity Anticancer

Activity Measurement 233.0 µM

Target

Cancer Type Brain Tumor

Cell Line U251-MG

Tissue Affected Brain

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2021

Evidence 4 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 112 µM

Detail Source Activity Anticancer

Activity Measurement 112 µM

Target

Cancer Type Breast Cancer

Cell Line MCF-7

Tissue Affected Breast

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2021

Evidence 5 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 33.69 µM

Detail Source Activity Anticancer

Activity Measurement 33.69 µM

Target

Cancer Type Colon Cancer

Cell Line HCT-116

Tissue Affected Colon

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2021