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Peptide record

TPDB15391

Antibacterial Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB15391
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia
standard
No
A 12-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Sequence
RICQFVLIRVCR
Physicochemical Analysis
C66H116N22O14S2
ANDEGHKMPSTWY
R
1505.91
10.82
3
0
6
+3
0.36
1.000
145.83
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
125
8.30
3
Residue Composition
number
0
A
3
R
0
N
0
D
2
C
0
E
1
Q
0
G
0
H
2
I
1
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 2 E: 0 Q: 1 G: 0 H: 0 I: 2 L: 1 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
12
C66H116N22O14S2
1505.91
10.82
+3
0.36
1.000
Evidence Records 2 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
10% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Dodecapeptide Cathelicidins of Cetartiodactyla: Structure, Mechanism of Antimicrobial Action, and Synergistic Interaction With Other Cathelicidins. | Front Microbiol | 2021
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Dodecapeptide Cathelicidins of Cetartiodactyla: Structure, Mechanism of Antimicrobial Action, and Synergistic Interaction With Other Cathelicidins. | Front Microbiol | 2021