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Peptide record

TPDB15373

American oyster defensin AOD (25-33) Antibacterial Antifungal Toxicity standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB15373
American oyster defensin AOD (25-33)
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia DBAASP
standard
No
A 9-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, and DBAASP, with an available 3D structural model.
Sequence
CAGSLRLTC
Physicochemical Analysis
C36H66N12O12S2
NDEQHIKMFPWYV
CL
923.11
8.30
1
0
3
+1
-0.68
0.889
97.78
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
13.54
4
Residue Composition
number
1
A
1
R
0
N
0
D
2
C
0
E
0
Q
1
G
0
H
0
I
2
L
0
K
0
M
0
F
0
P
1
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 2 K: 0 M: 0 F: 0 P: 0 S: 1 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C36H66N12O12S2
923.11
8.30
+1
-0.68
0.889
Evidence Records 3 records
Evidence 1 Activity

Activity

<5% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
<5% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial Activity and Action Mechanisms of Arg-Rich Short Analog Peptides Designed from the C-Terminal Loop Region of American Oyster Defensin (AOD) | Mar Drugs | 2021
Evidence 2 Activity

Activity

12-13% Cytotoxicity
Toxicity
100 µg/mL
Cytotoxic
12-13% Cytotoxicity | 100 | µg/mL | target cell: Human dermal fibroblasts

Target

Human dermal fibroblasts

Source & Reference

NA
DBAASP
Antimicrobial Activity and Action Mechanisms of Arg-Rich Short Analog Peptides Designed from the C-Terminal Loop Region of American Oyster Defensin (AOD) | Mar Drugs | 2021
Evidence 3 Activity

Target

Cutibacterium acnes

Source & Reference

DBAASP