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Peptide record

TPDB15337

P4 Antibacterial Anticancer standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB15337
P4
Antibacterial Anticancer
Anti-infective peptides Cancer-related peptides
dbAMP Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF
standard
No
A 20-aa standard natural multi-activity (Antibacterial and Anticancer) peptide sequence curated from dbAMP, Peptipedia, AntiCP 2.0, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
KWKLFKKIGIGKFLHLAKKF-NH2
Physicochemical Analysis
C123H196N30O21
RNDCEQMPSTYV
K
2431.10
11.29
8
0
10
+7
0.20
-0.080
102.50
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
226.24
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
1
H
2
I
3
L
7
K
0
M
3
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 1 I: 2 L: 3 K: 7 M: 0 F: 3 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
20
C123H196N30O21
2431.10
11.29
+7
0.20
-0.080
Amidation
L
Linear
Free
Antibacterial
Ceropin A-Magainin 2
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
IC50=1.9 µM
Anticancer
1.9 µM

Target

Lung Cancer
NCI-H69
Lung

Assay & Model

MTT/MTS assay
72-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
1997

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

IC50
IC50=1.3 µM
Anticancer
1.3 µM

Target

Lung Cancer
NCI-H128
Lung

Assay & Model

MTT/MTS assay
72-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
1997
Evidence 3 Activity

Activity

IC50
IC50=2.8 µM
Anticancer
2.8 µM

Target

Lung Cancer
NCI-H146
Lung

Assay & Model

MTT/MTS assay
72-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
1997