TPDB

3D PDB MODEL

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TPDB ID TPDB15321

Peptide_Name

Shiva-1

Activity

Antibacterial Anticancer Antifungal Antiparasitic

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

dbAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab

Sequence_Type

standard

Has_Modification No

Description A 38-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, Peptipedia, ACP740 _ACP240, and other sources, with an available 3D structural model.

Sequence

MPRWRLFRRIDRVGKQIKQGILRAGPAIALVGDARAVG

FASTA

>TPDB15321|Antibacterial;Anticancer;Antifungal;Antiparasitic|length=38
MPRWRLFRRIDRVGKQIKQGILRAGPAIALVGDARAVG

Formula C189H322N64O45S1

Absent Amino Acids NCEHSTY

Common Amino Acids R

Mass 4243.10

PI 12.53

Basic Residues 9

Acidic Residues 2

Hydrophobic Residues 18

Net Charge +7

Boman Index 5.45

Hydrophobicity -0.097

Aliphatic Index 107.89

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 129.62

Polar Residues 2

number

5

A

7

R

0

N

2

D

0

C

0

E

2

Q

5

G

0

H

4

I

3

L

2

K

1

M

1

F

2

P

0

S

0

T

1

W

0

Y

3

V

Amino Acid Distribution

A: 5 R: 7 N: 0 D: 2 C: 0 E: 0 Q: 2 G: 5 H: 0 I: 4 L: 3 K: 2 M: 1 F: 1 P: 2 S: 0 T: 0 W: 1 Y: 0 V: 3

Length

38

Formula

C189H322N64O45S1

Mass

4243.10

PI

12.53

Net Charge

+7

Boman Index

5.45

Hydrophobicity

-0.097

C_terminal_Modification

Free

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antibacterial

Origin

Magainin

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=28.7 µM

Detail Source Activity Anticancer

Activity Measurement 28.7 µM

Target

Cancer Type Leukemia Cancer

Cell Line K-562

Tissue Affected Blood

Assay & Model

Assay MTT assay

Testing Time 96-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1994

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=56 µM

Detail Source Activity Anticancer

Activity Measurement 56 µM

Target

Cancer Type Breast Cancer

Cell Line BTS-30

Tissue Affected Breast

Assay & Model

Assay MTT assay

Testing Time 96-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1994

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=49.3 µM

Detail Source Activity Anticancer

Activity Measurement 49.3 µM

Target

Cancer Type Colon Cancer

Cell Line HRT-18

Tissue Affected Colon

Assay & Model

Assay MTT assay

Testing Time 96-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1994

Evidence 4 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=>100 µM

Detail Source Activity Anticancer

Activity Measurement >100 µM

Target

Cancer Type Colon Cancer

Cell Line DLD-1

Tissue Affected Colon

Assay & Model

Assay MTT assay

Testing Time 96-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1994