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Peptide record

TPDB15300

Antibacterial Toxicity modified_plain modified
7 amino acids
Basic Information
3D PDB MODEL
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TPDB15300
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP DRAMP Peptipedia
modified_plain
Yes
A 7-aa modified multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP, DRAMP, and Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
KXWKLXK
Physicochemical Analysis
C35H59N9O6
ARNDCEQGHIMFPSTYV
K
701.91
10.84
3
0
2
+3
0.56
-1.257
55.71
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
783.58
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
3
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
7
C35H59N9O6
701.91
10.84
+3
0.56
-1.257
Evidence Records 3 records
Evidence 1 Activity

Activity

<1% Hemolysis
Toxicity
25-50 µM
Hemolytic Cytotoxic
<1% Hemolysis | 25-50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Mono-substitution effects on antimicrobial activity of stapled heptapeptides. | Arch Pharm Res | 2017
Evidence 2 Activity

Activity

<1% Hemolysis
Toxicity
6.3-12.5 µM
Hemolytic Cytotoxic
<1% Hemolysis | 6.3-12.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial and Hemolytic Activity of Stapled Heptapeptide Dimers | Bull Korean Chem Soc | 2016
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
1.12 %
Hemolytic
Hemolytic_activity: 0.88%, 0.72%, 0.90%, 1.25%, 0.75%, 0.98%, 1.03% and 1.12% hemolysis against human red blood cells at 0.8, 1.6, 3.1, 6.3, 12.5, 25.0, 50.0 and 100.0 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
B KOREAN CHEM SOC