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Peptide record

TPDB15297

Antibacterial Antifungal Toxicity modified_plain modified
11 amino acids
Basic Information
3D PDB MODEL
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TPDB15297
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP DRAMP Peptipedia CAFPdb
modified_plain
Yes
A 11-aa modified multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Modified, details unspecified
Sequence
WWVXAFAXRRR
Physicochemical Analysis
C60H86N20O10
NDCEQGHILKMPSTY
R
1247.47
12.70
3
0
6
+3
-2.67
-0.427
44.55
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
11000
881.78
0
Residue Composition
number
2
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
2
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 1
Chemical Descriptors
11
C60H86N20O10
1247.47
12.70
+3
-2.67
-0.427
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
4.49 µM
Hemolytic Cytotoxic
50% Hemolysis | 4.49 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Hydrocarbon-stapled lipopeptides exhibit selective antimicrobial activity. | Biopolymers | 2017
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
3.59 µM
Hemolytic Cytotoxic
50% Hemolysis | 3.59 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Hydrocarbon-stapled lipopeptides exhibit selective antimicrobial activity. | Biopolymers | 2017
Evidence 3 Activity

Activity

HC50
Toxicity
3.59 µM
Hemolytic
Hemolytic_activity: [Ref.28073163] HC50 = 3.59 µM against human red blood cells. Note: HC50 is the half-maximal hemolytic concentration.

Target

erythrocytes

Source & Reference

NA
DRAMP
Biopolymers. 2017 May 108(3). doi: 10.1002/bip.23006.