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Peptide record

TPDB15291

Antibacterial Antifungal Toxicity standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB15291
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP DRAMP Peptipedia CAFPdb
standard
No
A 7-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
IHHIHHI
Physicochemical Analysis
C42H63N15O8
ARNDCEQGLKMFPSTWYV
H
906.06
8.15
4
0
3
+0
2.91
0.100
167.14
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
4
H
3
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 4 I: 3 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
7
C42H63N15O8
906.06
8.15
+0
2.91
0.100
Evidence Records 3 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
>128 µM
Hemolytic Cytotoxic
10% Hemolysis | >128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Highly Stabilized ?-Helical Coiled Coils Kill Gram-Negative Bacteria by Multicomplementary Mechanisms under Acidic Condition. | ACS Appl Mater Interfaces | 2019
Evidence 2 Activity

Activity

10% Killing
Toxicity
>128 µM
Cytotoxic
10% Killing | >128 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Highly Stabilized ?-Helical Coiled Coils Kill Gram-Negative Bacteria by Multicomplementary Mechanisms under Acidic Condition. | ACS Appl Mater Interfaces | 2019
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
5 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.31199117] 5% hemolysis at 63µM, 8% hemolysis at 128µM against human red blood cells | Cytotoxicity: [Ref.31199117] ①The cell viability of HEK293T cells induced by 3IH1 is 105.6%, 101.1%, 100.6%, 102.5%, 100.3%, 101.4% and 101.1% at peptide concentrations of 2, 4, 8, 16, 32, 64 and 128 µM at pH 7.4, while that induced by Melittin is 47.2%, 1.7%, 1.9%, 0.6%, 0.6%, 0.6% and 1.7% at 2, 4, 8, 16, 32, 64 and 128 µM. ②The cell viability of HEK293T cells induced by 3IH1 is 102.2%, 103.1%, 102.0%, 103.4%, 103.1%, 102.0% and 101.7% at peptide concentrations of 2, 4, 8, 16, 32, 64 and 128 µM at pH 6.0, while that induced by Melittin is 43.8%, 3.4%, 3.4%, 0%, 2.2%, 0% and 1.1% at 2, 4, 8, 16, 32, 64 and 128 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
ACS Appl Mater Interfaces. 2019 Jun 26 11(25):22113-22128. doi: 10.1021/acsami.9b04654. Epub 2019 Jun 14.