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Peptide record

TPDB15289

[C/U, G1K, L5Y, K8R]cGm Antibacterial Anticancer Antifungal modified_plain modified
18 amino acids
Basic Information
3D PDB MODEL
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TPDB15289
[C/U, G1K, L5Y, K8R]cGm
Antibacterial Anticancer Antifungal
Anti-infective peptides Cancer-related peptides
dbAMP DRAMP Peptipedia CancerPPD 2.0 dbACP dbAMP 3.0 CAFPdb
modified_plain
Yes
A 18-aa modified multi-activity (Antibacterial, Anticancer, and Antifungal) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
C-terminal: Cyclized Chemical: U = SelenoCys N-terminal: Cyclized
Sequence
KURRYUYRQRUVTYURGR
Physicochemical Analysis
C85H140N34O20
ANDCEHILMFPSW
R
1958.26
12.12
7
0
4
+7
3.83
-1.956
16.11
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
4470
228.26
5
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
1
Q
1
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
1
T
0
W
3
Y
1
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 3 V: 1
Chemical Descriptors
18
C85H140N34O20
1958.26
12.12
+7
3.83
-1.956
Cyclized
U = SelenoCys
L
Cyclic
Cyclized
Antimicrobial
Synthetic Analogue of Gomesin
Evidence Records 6 records
Evidence 1 Activity

Activity

CC50
CC50 = 46.2 ± 7.6 µM
Anticancer
46.2

Target

Gastric Cancer
CRL-1739
Stomach

Assay & Model

Resazurin dye assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP
CancerPPD2
2017

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation. dbAMP 3.0 classified as Anticancer under the disease-associated peptide function classes.
Evidence 2 Activity

Activity

CC50
CC50 = 2.3 ± 0.2 µM
Anticancer
2.3

Target

Skin Cancer
MM96L
Skin

Assay & Model

Resazurin dye assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP
CancerPPD2
2017
Evidence 3 Activity

Activity

CC50
CC50 = 36.2 ± 2.8 µM
Anticancer
36.2

Target

Cervical Cancer
HeLa
Cervix

Assay & Model

Resazurin dye assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP
CancerPPD2
2017
Evidence 4 Activity

Activity

CC50
CC50 = 29.0 ± 3.7 µM
Anticancer
29.0

Target

Breast Cancer
MCF-7
Breast

Assay & Model

Resazurin dye assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP
CancerPPD2
2017
Evidence 5 Activity

Activity

CC50
CC50 = 6.4 ± 0.6 µM
Anticancer
6.4

Target

Leukemia Cancer
K-562
Blood

Assay & Model

Resazurin dye assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP
CancerPPD2
2017
Evidence 6 Activity

Activity

CC50
CC50 = 33.3 ±7.4µM
Anticancer
33.3

Target

Leukemia Cancer
HL-60
Blood

Assay & Model

Resazurin dye assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP
CancerPPD2
2017