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Peptide record

TPDB15288

[C/U]cGm Antibacterial Anticancer Antifungal modified_plain modified
18 amino acids
Basic Information
3D PDB MODEL
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TPDB15288
[C/U]cGm
Antibacterial Anticancer Antifungal
Anti-infective peptides Cancer-related peptides
dbAMP DRAMP Peptipedia CancerPPD 2.0 dbACP dbAMP 3.0 CAFPdb
modified_plain
Yes
A 18-aa modified multi-activity (Antibacterial, Anticancer, and Antifungal) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
C-terminal: Cyclized Chemical: U = SelenoCys N-terminal: Cyclized
Sequence
GURRLUYKQRUVTYURGR
Physicochemical Analysis
C78H133N31O19
ANDCEHIMFPSW
R
1809.11
12.24
6
0
4
+6
3.41
-1.444
37.78
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
2980
164.72
4
Residue Composition
number
0
A
5
R
0
N
0
D
0
C
0
E
1
Q
2
G
0
H
0
I
1
L
1
K
0
M
0
F
0
P
0
S
1
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 2 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 2 V: 1
Chemical Descriptors
18
C78H133N31O19
1809.11
12.24
+6
3.41
-1.444
Cyclized
U = SelenoCys
L
Cyclic
Cyclized
Antimicrobial
Synthetic Analogue of Gomesin
Evidence Records 6 records
Evidence 1 Activity

Activity

CC50
CC50 = 51.0 ± 4.6 µM
Anticancer
51.0

Target

Gastric Cancer
CRL-1739
Stomach

Assay & Model

Resazurin dye assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP
CancerPPD2
2017

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation. dbAMP 3.0 classified as Anticancer under the disease-associated peptide function classes.
Evidence 2 Activity

Activity

CC50
CC50 = 4.6 ± 0.2 µM
Anticancer
4.6

Target

Skin Cancer
MM96L
Skin

Assay & Model

Resazurin dye assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP
CancerPPD2
2017
Evidence 3 Activity

Activity

CC50
CC50 > 64 µM
Anticancer
64 µM

Target

Cervical Cancer
HeLa
Cervix

Assay & Model

Resazurin dye assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP
CancerPPD2
2017
Evidence 4 Activity

Activity

CC50
CC50 = 37.5 ± 3.3 µM
Anticancer
37.5

Target

Breast Cancer
MCF-7
Breast

Assay & Model

Resazurin dye assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP
CancerPPD2
2017
Evidence 5 Activity

Activity

CC50
CC50 = 1.4 ± 0.2 µM
Anticancer
1.4

Target

Leukemia Cancer
K-562
Blood

Assay & Model

Resazurin dye assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP
CancerPPD2
2017
Evidence 6 Activity

Activity

CC50
CC50 = 38.5 ± 4.8 µM
Anticancer
38.5

Target

Leukemia Cancer
HL-60
Blood

Assay & Model

Resazurin dye assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP
CancerPPD2
2017