TPDB

3D PDB MODEL

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TPDB ID TPDB15284

Activity

Antibacterial Antifungal Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

dbAMP DRAMP Peptipedia CAFPdb PD_Hemolysis

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.

Sequence

GLLKRIK

FASTA

>TPDB15284|Antibacterial;Antifungal;Hemolysis;Toxicity|length=7
GLLKRIK

Formula C38H74N12O8

Absent Amino Acids ANDCEQHMFPSTWYV

Common Amino Acids LK

Mass 827.08

PI 11.64

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 3

Net Charge +3

Boman Index 1.37

Hydrophobicity -0.086

Aliphatic Index 167.14

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

1

R

0

N

0

D

0

C

0

E

0

Q

1

G

0

H

1

I

2

L

2

K

0

M

0

F

0

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 2 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

7

Formula

C38H74N12O8

Mass

827.08

PI

11.64

Net Charge

+3

Boman Index

1.37

Hydrophobicity

-0.086

Evidence 1 Activity

Activity

Activity Endpoint HC50

Detail Source Activity Hemolysis

Activity Measurement 37.70 µg/mL

Hemolysis Raw

[Ref.29614317] HC50=37.70µg/mL against human red blood cells

Target

RBC Target human red blood cells

Source & Reference

Database Source Hemolytik PD_Hemolysis

Source DRAMP4

Reference

Peptides. 2018 Jun 104:7-14.

Other

Source Activity Label	Source Definition
Hemolysis	Hemolytik experimentally validated hemolytic peptide annotation.

Evidence 2 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 37.70 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 37.70 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Effects of truncation of the peptide chain on the secondary structure and bioactivities of palmitoylated anoplin. | Peptides | 2018

Evidence 3 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

- | NA | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Structure-activity relationship study of anoplin. | J Pept Sci | 2005

Evidence 4 Activity

Activity

Activity Endpoint HC50

Detail Source Activity Toxicity

Activity Measurement 37.70 µg/mL

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.29614317] HC50=37.70µg/mL against human red blood cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Peptides. 2018 Jun 104:7-14.

Evidence 5 Hemolysis

Activity

Activity Measurement 37.70 µg/mL

Activity Endpoint HC50

Hemolysis Raw

[Ref.29614317] HC50=37.70µg/mL against human red blood cells

Detail Source Activity Hemolysis

Target

RBC Target human red blood cells

Source & Reference

source PD_Hemolysis

Reference

Peptides. 2018 Jun 104:7-14.

Source DRAMP4

Database Source PD_Hemolysis