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Peptide record

TPDB15275

Antibacterial Toxicity standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB15275
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP DRAMP Peptipedia
standard
No
A 7-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP, DRAMP, and Peptipedia, with an available 3D structural model.
Sequence
FRIRVRV
Physicochemical Analysis
C43H76N16O8
ANDCEQGHLKMPSTWY
R
945.18
12.70
3
0
4
+3
1.13
0.314
138.57
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
7
C43H76N16O8
945.18
12.70
+3
1.13
0.314
Evidence Records 3 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
4 µM
Hemolytic Cytotoxic
5% Hemolysis | 4 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
High Specific Selectivity and Membrane-Active Mechanism of Synthetic Cationic Hybrid Antimicrobial Peptides Based on the Peptide FV7. | Int J Mol Sci | 2017
Evidence 2 Activity

Activity

15% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
15% Hemolysis | 128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
High Specific Selectivity and Membrane-Active Mechanism of Synthetic Cationic Hybrid Antimicrobial Peptides Based on the Peptide FV7. | Int J Mol Sci | 2017
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
3 %
Hemolytic
Hemolytic_activity: [Ref.28178190] 3% hemolysis at 128 µM against human red cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Mol Sci. 2017 Feb 6 18(2).