Back to search

Peptide record

TPDB15272

Antibacterial Antifungal standard
7 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB15272
Antibacterial Antifungal
Anti-infective peptides
dbAMP DRAMP Peptipedia CAFPdb
standard
No
A 7-aa standard-residue multi-activity (Antibacterial and Antifungal) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
DDDDDDD
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C28H37N7O22
ARNCEQGHILKMFPSTWYV
D
823.64
2.59
0
7
0
-7
8.72
-3.500
0.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
7
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 7 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
7 reviewed residue count
C28H37N7O22 sequence-only estimate (linear, free termini)
823.64 sequence-only estimate (linear, free termini)
2.59 sequence-only estimate (linear, free termini)
-7 sequence-only estimate (linear, free termini)
8.72 sequence-only estimate (linear, free termini)
-3.500 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against (kill) P. haemolytica (MBC50 20 uM), K.pneumoniae ATCC 10031 (MBC50 0.62 mM), E.coli ATCC 12795 (MBC50 0.64 mM), S.aureus ATCC 29213 (MBC50 1.21 mM), and S.faecalis ATCC 29212 (MBC50 1.39 mM) in Zinc-containing buffer 0.14 NaCl/10 uM ZnCl2 (see ref). A recent study tested additional bacteria and found this peptide was inactive (MIC> 512 ug/ml). These include E.faecium BAA-2317, S.aureus ATCC 43300 (MRSA-inactive), K.pneumoniae 700603, A.baumannii 19606, P.aeruginosa 27853, E.coli ATCC 25922 and C.albicans 10231 ( Miller et al., 2023 ) (Provided by Adriana Miller).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against (kill) P. haemolytica (MBC50 20 uM), K.pneumoniae ATCC 10031 (MBC50 0.62 mM), E.coli ATCC 12795 (MBC50 0.64 mM), S.aureus ATCC 29213 (MBC50 1.21 mM), and S.faecalis ATCC 29212 (MBC50 1.39 mM) in Zinc-containing buffer 0.14 NaCl/10 uM ZnCl2 (see ref). A recent study tested additional bacteria and found this peptide was inactive (MIC> 512 ug/ml). These include E.faecium BAA-2317, S.aureus ATCC 43300 (MRSA-inactive), K.pneumoniae 700603, A.baumannii 19606, P.aeruginosa 27853, E.coli ATCC 25922 and C.albicans 10231 ( Miller et al., 2023 ) (Provided by Adriana Miller).