Back to search

Peptide record

TPDB15262

Antibacterial Antifungal Toxicity modified_plain modified
18 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB15262
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP DRAMP Peptipedia CAFPdb
modified_plain
Yes
A 18-aa modified multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Modified, details unspecified
Sequence
GFLSILKKVLPKVXAHXK
Physicochemical Analysis
C86H148N22O18
RNDCEQMTWY
K
1778.26
11.00
5
0
8
+4
2.36
0.406
124.44
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
1
H
1
I
3
L
4
K
0
M
1
F
1
P
1
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 1 L: 3 K: 4 M: 0 F: 1 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
18
C86H148N22O18
1778.26
11.00
+4
2.36
0.406
Evidence Records 7 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
50% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effect of hydrocarbon stapling on the properties of ?-helical antimicrobial peptides isolated from the venom of hymenoptera | Amino Acids | 2012
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>200 µM
Hemolytic Cytotoxic
50% Hemolysis | >200 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Melectin MAPs: the influence of dendrimerization on antimicrobial and hemolytic activity. | Amino Acids | 2010
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
35.0 µM
Hemolytic Cytotoxic
50% Hemolysis | 35.0 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Melectin MAPs: the influence of dendrimerization on antimicrobial and hemolytic activity. | Amino Acids | 2010
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
12.7 µM
Hemolytic Cytotoxic
50% Hemolysis | 12.7 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Melectin MAPs: the influence of dendrimerization on antimicrobial and hemolytic activity. | Amino Acids | 2010
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
18 µM
Hemolytic Cytotoxic
50% Hemolysis | 18 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Melectin MAPs: the influence of dendrimerization on antimicrobial and hemolytic activity. | Amino Acids | 2010
Evidence 6 Activity

Activity

50% Hemolysis
Toxicity
11.8 µM
Hemolytic Cytotoxic
50% Hemolysis | 11.8 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Melectin MAPs: the influence of dendrimerization on antimicrobial and hemolytic activity. | Amino Acids | 2010
Evidence 7 Activity

Activity

LC50
Toxicity
50 µM
Hemolytic
Hemolytic_activity: [Ref.22526241]LC50=50 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Amino Acids. 2012 Nov 43(5):2047-58.