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Peptide record

TPDB15156

Gomesin Antibacterial Anticancer Antifungal Antiparasitic Toxicity modified_plain modified
18 amino acids
Basic Information
3D PDB MODEL
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TPDB15156
Gomesin
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
dbAMP DRAMP Peptipedia CancerPPD 2.0 dbACP dbAMP 3.0 CAFPdb
modified_plain
Yes
A 18-aa modified multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
C-terminal: Amidation Chemical: Z= pyroglutamic acid
Sequence
ZCRRLCYKQRCVTYCRGR-NH2
Physicochemical Analysis
C88H150N34O22S4
ANDEHIMFPSW
R
2164.61
10.10
6
0
4
+6
2.44
-0.867
37.78
Mammalian: Yeast: E.coli:
3230
149.22
8
Residue Composition
number
0
A
5
R
0
N
0
D
4
C
0
E
1
Q
1
G
0
H
0
I
1
L
1
K
0
M
0
F
0
P
0
S
1
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 4 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 2 V: 1
Chemical Descriptors
18
C88H150N34O22S4
2164.61
10.10
+6
2.44
-0.867
Amidation
Z= pyroglutamic acid
L
Cyclic
Free
Antimicrobial and Anticancer
Acanthoscurria gomesiana
Evidence Records 2 records
Evidence 1 Activity

Activity

CC50
CC50 = 5.5 ± 1.1 µM
Anticancer
5.5

Target

Skin Cancer
MM96L
Skin

Assay & Model

Resazurin dye assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP
CancerPPD2
2017

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation. dbAMP 3.0 classified as Anticancer under the disease-associated peptide function classes.
Evidence 2 Activity

Activity

CC50
CC50 = 5.5 ± 1.1 µM
Anticancer
5.5

Target

Blood Cancer
K-562
Blood

Assay & Model

Resazurin dye assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP
CancerPPD2
2017