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Peptide record

TPDB15141

Neuropeptide Y Antibacterial Antifungal Blood-Brain Barrier Neuropeptide standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB15141
Neuropeptide Y
Antibacterial Antifungal Blood-Brain Barrier Neuropeptide
Anti-infective peptides Delivery and barrier-penetrating peptides Neuroactive peptides
dbAMP DRAMP Peptipedia CAFPdb BBPpredict
standard
No
A 36-aa standard natural multi-activity (Antibacterial, Antifungal, Blood-Brain Barrier, and other sources) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
YPSKPDNPGEDAPAEDLARYYSALRHYINLITRQRY
Physicochemical Analysis
C190H286N54O58
CMFWV
Y
4254.69
7.60
6
5
14
+0
8.87
-1.142
65.28
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
7450
175.10
11
Residue Composition
number
4
A
4
R
2
N
3
D
0
C
2
E
1
Q
1
G
1
H
2
I
3
L
1
K
0
M
0
F
4
P
2
S
1
T
0
W
5
Y
0
V
Amino Acid Distribution
A: 4 R: 4 N: 2 D: 3 C: 0 E: 2 Q: 1 G: 1 H: 1 I: 2 L: 3 K: 1 M: 0 F: 0 P: 4 S: 2 T: 1 W: 0 Y: 5 V: 0
Chemical Descriptors
36
C190H286N54O58
4254.69
7.60
+0
8.87
-1.142
Linear
Similarity
Tyr-Pro- Ser-Lys -Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala - Pro-Ala -Glu-Asp-Leu-AIa-Arg-Tyr -Tyr- Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr
CCC(C)C(C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)CC)C(=O)NC(C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CC3=CN=CN3)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(CCCNC(=N)N)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C6CCCN6C(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C7CCCN7C(=O)C(CC(=O)N)NC(=O)C(CC(=O)O)NC(=O)C8CCCN8C(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C9CCCN9C(=O)C(CC1=CC=C(C=C1)O)N
Evidence Records 5 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
0.000194 mL/(g x min)

Assay & Model

Origin/Source
Unidirectional influx rate constant

Source & Reference

NA
B3Pdb

Other

bovine,porcine
Intravenous
non saturable
Direct iodination
Evidence 2 Activity

Activity

Blood-Brain Barrier
23.3 min

Assay & Model

Efflux study ICU
Origin/Source
half life, brain

Source & Reference

NA
B3Pdb

Other

bovine,porcine
Permeability
Direct iodination
Evidence 3 Activity

Activity

Blood-Brain Barrier
0.03 min-1

Assay & Model

Efflux study ICU
Origin/Source
Brain elemination rate constant

Source & Reference

NA
B3Pdb

Other

bovine,porcine
Permeability
Direct iodination
Evidence 4 Activity

Activity

Neuropeptide

Target

Neuropeptide Y receptor type 1 Neuropeptide Y receptor type 2
Bos taurus Bos taurus

Source & Reference

NA
NeuroPepV2

Other

Bos taurus
NPY
383 384
NP07545 NP07599 NP07687 NP07545 NP07599 NP07687
Evidence 5 Activity

Activity

Neuropeptide

Target

Neuropeptide Y receptor type 1 Neuropeptide Y receptor type 2 Neuropeptide Y receptor type 5
Sus scrofa Sus scrofa Sus scrofa

Source & Reference

NA
NeuroPepV2

Other

Sus scrofa
NPY
383 382 446
NP07614 NP07556 NP07691 NP07697 NP07614 NP07556 NP07691 NP07697 NP07614 NP07556 NP07691 NP07697
Additional Detail Fields 4 fields
NPY
Intravenous
383 384 382 446
NP07545 NP07599 NP07687 NP07614 NP07556 NP07691 NP07697