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Peptide record

TPDB15042

Antibacterial Antifungal Toxicity standard
80 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB15042
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia AFP-GFuse Antifungipept CAFPdb
standard
No
A 80-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
TDTNVIGECFDEWSRCHRQTRWWTKILFQSCENRCKCKVQLMGNCIKVPFKCFLWKQKRFMCECYGPISGTKPWYCGWEL
Physicochemical Analysis
C435H652N118O112S12
A
C
9711.41
8.47
14
7
26
+6
6.80
-0.475
49.88
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
36605
376.93
27
Residue Composition
number
0
A
5
R
3
N
2
D
10
C
5
E
4
Q
5
G
1
H
4
I
4
L
8
K
2
M
5
F
3
P
3
S
5
T
6
W
2
Y
3
V
Amino Acid Distribution
A: 0 R: 5 N: 3 D: 2 C: 10 E: 5 Q: 4 G: 5 H: 1 I: 4 L: 4 K: 8 M: 2 F: 5 P: 3 S: 3 T: 5 W: 6 Y: 2 V: 3
Chemical Descriptors
80
C435H652N118O112S12
9711.41
8.47
+6
6.80
-0.475
Evidence Records 18 records
Evidence 1 Activity

Activity

MIC
Antibacterial
7.5 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against E. coli ATCC 25922 (MIC 7.5 ug/ml), S. aureus ATCC 25923 (MIC 1.9 ug/ml), B. pyocyaneus CMCCB 10104 (MIC 3.75 ug/ml), B. meg
Evidence 2 Activity

Activity

MIC
Antibacterial
1.9 µg/mL

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP

Other

Active against E. coli ATCC 25922 (MIC 7.5 ug/ml), S. aureus ATCC 25923 (MIC 1.9 ug/ml), B. pyocyaneus CMCCB 10104 (MIC 3.75 ug/ml), B. megatherium (MIC 15 ug/ml), B. dysenteria
Evidence 3 Activity

Activity

MIC
Antibacterial
3.75 µg/mL

Target

B. pyocyaneus CMCCB 10104

Source & Reference

dbAMP

Other

Active against E. coli ATCC 25922 (MIC 7.5 ug/ml), S. aureus ATCC 25923 (MIC 1.9 ug/ml), B. pyocyaneus CMCCB 10104 (MIC 3.75 ug/ml), B. megatherium (MIC 15 ug/ml), B. dysenteriae (MIC 3.75 ug/ml), K. pneumoniae (MIC 30 ug
Evidence 4 Activity

Activity

MIC
Antibacterial
15 µg/mL

Target

B. megatherium

Source & Reference

dbAMP

Other

ug/ml), S. aureus ATCC 25923 (MIC 1.9 ug/ml), B. pyocyaneus CMCCB 10104 (MIC 3.75 ug/ml), B. megatherium (MIC 15 ug/ml), B. dysenteriae (MIC 3.75 ug/ml), K. pneumoniae (MIC 30 ug/ml), and C. albicans ATCC 2003
Evidence 5 Activity

Activity

MIC
Antibacterial
3.75 µg/mL

Target

B. dysenteriae

Source & Reference

dbAMP

Other

IC 1.9 ug/ml), B. pyocyaneus CMCCB 10104 (MIC 3.75 ug/ml), B. megatherium (MIC 15 ug/ml), B. dysenteriae (MIC 3.75 ug/ml), K. pneumoniae (MIC 30 ug/ml), and C. albicans ATCC 20032 (MIC 7.5 ug/ml). Toxicity: At t
Evidence 6 Activity

Activity

MIC
Antibacterial
30 µg/mL

Target

Klebsiella pneumoniae

Source & Reference

dbAMP

Other

B 10104 (MIC 3.75 ug/ml), B. megatherium (MIC 15 ug/ml), B. dysenteriae (MIC 3.75 ug/ml), K. pneumoniae (MIC 30 ug/ml), and C. albicans ATCC 20032 (MIC 7.5 ug/ml). Toxicity: At the concentration of 5, 10, 20,
Evidence 7 Activity

Activity

MIC
Antibacterial
7.5 µg/mL

Target

Candida albicans ATCC 20032

Source & Reference

dbAMP

Other

herium (MIC 15 ug/ml), B. dysenteriae (MIC 3.75 ug/ml), K. pneumoniae (MIC 30 ug/ml), and C. albicans ATCC 20032 (MIC 7.5 ug/ml). Toxicity: At the concentration of 5, 10, 20, 40, 80, 160, and 320 ug/ml, respectively, i
Evidence 8 Activity

Activity

MIC
Antifungal
7.5 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against E. coli ATCC 25922 (MIC 7.5 ug/ml), S. aureus ATCC 25923 (MIC 1.9 ug/ml), B. pyocyaneus CMCCB 10104 (MIC 3.75 ug/ml), B. meg
Evidence 9 Activity

Activity

MIC
Antifungal
1.9 µg/mL

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against E. coli ATCC 25922 (MIC 7.5 ug/ml), S. aureus ATCC 25923 (MIC 1.9 ug/ml), B. pyocyaneus CMCCB 10104 (MIC 3.75 ug/ml), B. megatherium (MIC 15 ug/ml), B. dysenteria
Evidence 10 Activity

Activity

MIC
Antifungal
3.75 µg/mL

Target

B. pyocyaneus CMCCB 10104

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against E. coli ATCC 25922 (MIC 7.5 ug/ml), S. aureus ATCC 25923 (MIC 1.9 ug/ml), B. pyocyaneus CMCCB 10104 (MIC 3.75 ug/ml), B. megatherium (MIC 15 ug/ml), B. dysenteriae (MIC 3.75 ug/ml), K. pneumoniae (MIC 30 ug
Evidence 11 Activity

Activity

MIC
Antifungal
15 µg/mL

Target

B. megatherium

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ug/ml), S. aureus ATCC 25923 (MIC 1.9 ug/ml), B. pyocyaneus CMCCB 10104 (MIC 3.75 ug/ml), B. megatherium (MIC 15 ug/ml), B. dysenteriae (MIC 3.75 ug/ml), K. pneumoniae (MIC 30 ug/ml), and C. albicans ATCC 2003
Evidence 12 Activity

Activity

MIC
Antifungal
3.75 µg/mL

Target

B. dysenteriae

Source & Reference

dbAMP CAFPdb Antifungipept

Other

IC 1.9 ug/ml), B. pyocyaneus CMCCB 10104 (MIC 3.75 ug/ml), B. megatherium (MIC 15 ug/ml), B. dysenteriae (MIC 3.75 ug/ml), K. pneumoniae (MIC 30 ug/ml), and C. albicans ATCC 20032 (MIC 7.5 ug/ml). Toxicity: At t
Evidence 13 Activity

Activity

MIC
Antifungal
30 µg/mL

Target

Klebsiella pneumoniae

Source & Reference

dbAMP CAFPdb Antifungipept

Other

B 10104 (MIC 3.75 ug/ml), B. megatherium (MIC 15 ug/ml), B. dysenteriae (MIC 3.75 ug/ml), K. pneumoniae (MIC 30 ug/ml), and C. albicans ATCC 20032 (MIC 7.5 ug/ml). Toxicity: At the concentration of 5, 10, 20,
Evidence 14 Activity

Activity

MIC
Antifungal
7.5 µg/mL

Target

Candida albicans ATCC 20032

Source & Reference

dbAMP CAFPdb Antifungipept

Other

herium (MIC 15 ug/ml), B. dysenteriae (MIC 3.75 ug/ml), K. pneumoniae (MIC 30 ug/ml), and C. albicans ATCC 20032 (MIC 7.5 ug/ml). Toxicity: At the concentration of 5, 10, 20, 40, 80, 160, and 320 ug/ml, respectively, i
Evidence 15 Activity

Activity

1% Hemolysis
Toxicity
10 µg/mL
Hemolytic Cytotoxic
1% Hemolysis | 10 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A novel cysteine-rich antimicrobial peptide from the mucus of the snail of Achatina fulica. | Peptides | 2013
Evidence 16 Activity

Activity

2% Hemolysis
Toxicity
80 µg/mL
Hemolytic Cytotoxic
2% Hemolysis | 80 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A novel cysteine-rich antimicrobial peptide from the mucus of the snail of Achatina fulica. | Peptides | 2013
Evidence 17 Activity

Activity

3% Hemolysis
Toxicity
160 µg/mL
Hemolytic Cytotoxic
3% Hemolysis | 160 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A novel cysteine-rich antimicrobial peptide from the mucus of the snail of Achatina fulica. | Peptides | 2013
Evidence 18 Activity

Activity

4% Hemolysis
Toxicity
320 µg/mL
Hemolytic Cytotoxic
4% Hemolysis | 320 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A novel cysteine-rich antimicrobial peptide from the mucus of the snail of Achatina fulica. | Peptides | 2013