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Peptide record

TPDB15017

Antibacterial Antifungal Antiparasitic standard
69 amino acids
Basic Information
3D PDB MODEL
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TPDB15017
Antibacterial Antifungal Antiparasitic
Anti-infective peptides
dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP 3.0 i2APP
standard
No
A 69-aa standard natural multi-activity (Antibacterial, Antifungal, and Antiparasitic) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
SNFDCCLGYTDRILHPKFIVGFTRQLANEGCDINAIIFHTKKKLSVCANPKQTWVKYIVRLLSKKVKNM
Physicochemical Analysis
C360H579N99O94S5
K
7958.46
10.06
14
4
28
+8
9.29
-0.106
93.19
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
8730
109.69
20
Residue Composition
number
3
A
3
R
5
N
3
D
4
C
1
E
2
Q
3
G
2
H
6
I
6
L
9
K
1
M
4
F
2
P
3
S
4
T
1
W
2
Y
5
V
Amino Acid Distribution
A: 3 R: 3 N: 5 D: 3 C: 4 E: 1 Q: 2 G: 3 H: 2 I: 6 L: 6 K: 9 M: 1 F: 4 P: 2 S: 3 T: 4 W: 1 Y: 2 V: 5
Chemical Descriptors
69
C360H579N99O94S5
7958.46
10.06
+8
9.29
-0.106
Evidence Records 12 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.46 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
cans 90028 (LD50 25 ug/ml), and C. neoforman 96-1043 (LD50 80 ug/ml). Also active against E. coli (MIC 0.46 uM), S. coag. neg. spp (MIC 1.58 uM), Propionibacterium spp (MIC 5.23 uM), S. aureus (MIC 5.5
Evidence 2 Activity

Activity

MIC
Antibacterial
1.58 µM

Target

g. spp

Source & Reference

dbAMP DRAMP

Other

neoforman 96-1043 (LD50 80 ug/ml). Also active against E. coli (MIC 0.46 uM), S. coag. neg. spp (MIC 1.58 uM), Propionibacterium spp (MIC 5.23 uM), S. aureus (MIC 5.54 uM), and Fungi: C. albicans (MI
Evidence 3 Activity

Activity

MIC
Antibacterial
5.54 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

coli (MIC 0.46 uM), S. coag. neg. spp (MIC 1.58 uM), Propionibacterium spp (MIC 5.23 uM), S. aureus (MIC 5.54 uM), and Fungi: C. albicans (MIC 0.09 uM) (Data from Maerki C et al. 2009 J Immunol 182: 506-
Evidence 4 Activity

Activity

MIC
Antibacterial
0.09 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

p (MIC 1.58 uM), Propionibacterium spp (MIC 5.23 uM), S. aureus (MIC 5.54 uM), and Fungi: C. albicans (MIC 0.09 uM) (Data from Maerki C et al. 2009 J Immunol 182: 506-514). More active against bacteria tha
Evidence 5 Activity

Activity

MIC
Antifungal
0.46 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
cans 90028 (LD50 25 ug/ml), and C. neoforman 96-1043 (LD50 80 ug/ml). Also active against E. coli (MIC 0.46 uM), S. coag. neg. spp (MIC 1.58 uM), Propionibacterium spp (MIC 5.23 uM), S. aureus (MIC 5.5
Evidence 6 Activity

Activity

MIC
Antifungal
1.58 µM

Target

g. spp

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

neoforman 96-1043 (LD50 80 ug/ml). Also active against E. coli (MIC 0.46 uM), S. coag. neg. spp (MIC 1.58 uM), Propionibacterium spp (MIC 5.23 uM), S. aureus (MIC 5.54 uM), and Fungi: C. albicans (MI
Evidence 7 Activity

Activity

MIC
Antifungal
5.54 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

coli (MIC 0.46 uM), S. coag. neg. spp (MIC 1.58 uM), Propionibacterium spp (MIC 5.23 uM), S. aureus (MIC 5.54 uM), and Fungi: C. albicans (MIC 0.09 uM) (Data from Maerki C et al. 2009 J Immunol 182: 506-
Evidence 8 Activity

Activity

MIC
Antifungal
0.09 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

p (MIC 1.58 uM), Propionibacterium spp (MIC 5.23 uM), S. aureus (MIC 5.54 uM), and Fungi: C. albicans (MIC 0.09 uM) (Data from Maerki C et al. 2009 J Immunol 182: 506-514). More active against bacteria tha
Evidence 9 Activity

Activity

MIC
Antiparasitic
0.46 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
cans 90028 (LD50 25 ug/ml), and C. neoforman 96-1043 (LD50 80 ug/ml). Also active against E. coli (MIC 0.46 uM), S. coag. neg. spp (MIC 1.58 uM), Propionibacterium spp (MIC 5.23 uM), S. aureus (MIC 5.5
Evidence 10 Activity

Activity

MIC
Antiparasitic
1.58 µM

Target

g. spp

Source & Reference

dbAMP 3.0 DRAMP

Other

neoforman 96-1043 (LD50 80 ug/ml). Also active against E. coli (MIC 0.46 uM), S. coag. neg. spp (MIC 1.58 uM), Propionibacterium spp (MIC 5.23 uM), S. aureus (MIC 5.54 uM), and Fungi: C. albicans (MI
Evidence 11 Activity

Activity

MIC
Antiparasitic
5.54 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0 DRAMP

Other

coli (MIC 0.46 uM), S. coag. neg. spp (MIC 1.58 uM), Propionibacterium spp (MIC 5.23 uM), S. aureus (MIC 5.54 uM), and Fungi: C. albicans (MIC 0.09 uM) (Data from Maerki C et al. 2009 J Immunol 182: 506-
Evidence 12 Activity

Activity

MIC
Antiparasitic
0.09 µM

Target

Candida albicans

Source & Reference

dbAMP 3.0 DRAMP

Other

p (MIC 1.58 uM), Propionibacterium spp (MIC 5.23 uM), S. aureus (MIC 5.54 uM), and Fungi: C. albicans (MIC 0.09 uM) (Data from Maerki C et al. 2009 J Immunol 182: 506-514). More active against bacteria tha