Back to search

Peptide record

TPDB14988

Anti-inflammatory Antibacterial Antifungal Antiviral standard
107 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB14988
Anti-inflammatory Antibacterial Antifungal Antiviral
Anti-infective peptides Immunity and inflammation peptides
Peptipedia dbAMP Antifungipept CAFPdb dbAMP 3.0
standard
No
A 107-aa standard natural multi-activity (Anti-inflammatory, Antibacterial, Antifungal, and other sources) peptide sequence curated from Peptipedia, dbAMP, Antifungipept, and other sources, with an available 3D structural model.
Sequence
SGKSFKAGVCPPKKSAQCLRYKKPECQSDWQCPGKKRCCPDTCGIKCLDPVDTPNPTRRKPGKCPVTYGQCLMLNPPNFCEMDGQCKRDLKCCMGMCGKSCVSPVKA
Physicochemical Analysis
C493H808N146O144S20
H
C
11725.93
8.74
20
8
23
+11
27.74
-0.649
38.22
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
9480
80.85
36
Residue Composition
number
3
A
5
R
3
N
6
D
16
C
2
E
5
Q
9
G
0
H
1
I
5
L
15
K
4
M
2
F
13
P
6
S
4
T
1
W
2
Y
5
V
Amino Acid Distribution
A: 3 R: 5 N: 3 D: 6 C: 16 E: 2 Q: 5 G: 9 H: 0 I: 1 L: 5 K: 15 M: 4 F: 2 P: 13 S: 6 T: 4 W: 1 Y: 2 V: 5
Chemical Descriptors
107
C493H808N146O144S20
11725.93
8.74
+11
27.74
-0.649
Evidence Records 3 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Likely kills S. aureus and E. coli. Active against metabolically active fungi A. fumigatus and C. albicans but not metabolically quiescent forms. Antifungal activity is localized to the N-terminal region ( Tomee JF et al., 1997) ). It seems that the N-terminal domain is responsible for antimicrobial activity. It also inhibits neutrophil elastase and other enzymes via its C-terminal domain, especially Leu72-Met73 residues. Virus: It also inhibts HIV-1 and HIV-2, free form ( Hocini et al., 2000 ). It may constitute a major shield from HIV infection orally ( Stergios Doumas et al., 2005 ). Proteases: inhibits chymotrypsin, leukocyte elastase, and trypsin. Anti-inflammatory:e.g., see Song et al. 1999 . It can binds to LPS in vitro, thereby blocking its transfer to soluble CD14 and uptake by macrophages ( Ding et al., 1999 ). Cancer: inhibited mammary tumor but not colon tumor growth ( Amiano et al., 2013 ). Promotes the tumorigenic and metastatic potential of cancer cells ( Devoogdt et al., 2003 ).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Likely kills S. aureus and E. coli. Active against metabolically active fungi A. fumigatus and C. albicans but not metabolically quiescent forms. Antifungal activity is localized to the N-terminal region ( Tomee JF et al., 1997) ). It seems that the N-terminal domain is responsible for antimicrobial activity. It also inhibits neutrophil elastase and other enzymes via its C-terminal domain, especially Leu72-Met73 residues. Virus: It also inhibts HIV-1 and HIV-2, free form ( Hocini et al., 2000 ). It may constitute a major shield from HIV infection orally ( Stergios Doumas et al., 2005 ). Proteases: inhibits chymotrypsin, leukocyte elastase, and trypsin. Anti-inflammatory:e.g., see Song et al. 1999 . It can binds to LPS in vitro, thereby blocking its transfer to soluble CD14 and uptake by macrophages ( Ding et al., 1999 ). Cancer: inhibited mammary tumor but not colon tumor growth ( Amiano et al., 2013 ). Promotes the tumorigenic and metastatic potential of cancer cells ( Devoogdt et al., 2003 ).
Evidence 3 Activity

Activity

Antiviral

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
Likely kills S. aureus and E. coli. Active against metabolically active fungi A. fumigatus and C. albicans but not metabolically quiescent forms. Antifungal activity is localized to the N-terminal region ( Tomee JF et al., 1997) ). It seems that the N-terminal domain is responsible for antimicrobial activity. It also inhibits neutrophil elastase and other enzymes via its C-terminal domain, especially Leu72-Met73 residues. Virus: It also inhibts HIV-1 and HIV-2, free form ( Hocini et al., 2000 ). It may constitute a major shield from HIV infection orally ( Stergios Doumas et al., 2005 ). Proteases: inhibits chymotrypsin, leukocyte elastase, and trypsin. Anti-inflammatory:e.g., see Song et al. 1999 . It can binds to LPS in vitro, thereby blocking its transfer to soluble CD14 and uptake by macrophages ( Ding et al., 1999 ). Cancer: inhibited mammary tumor but not colon tumor growth ( Amiano et al., 2013 ). Promotes the tumorigenic and metastatic potential of cancer cells ( Devoogdt et al., 2003 ).