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Peptide record

TPDB14959

Antibacterial Antifungal Toxicity standard
53 amino acids
Basic Information
3D PDB MODEL
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TPDB14959
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia AFP-GFuse Antifungipept CAFPdb
standard
No
A 53-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
RRSKARGGSRGSKMGRKDSKGGSRGRPGSGSRPGGGSSIAGASRGDRGGTRNA
Physicochemical Analysis
C201H357N91O70S1
CEQHLFWYV
G
5200.67
12.83
15
2
6
+13
17.03
-1.515
14.91
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
12
Residue Composition
number
4
A
11
R
1
N
2
D
0
C
0
E
0
Q
16
G
0
H
1
I
0
L
4
K
1
M
0
F
2
P
10
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 11 N: 1 D: 2 C: 0 E: 0 Q: 0 G: 16 H: 0 I: 1 L: 0 K: 4 M: 1 F: 0 P: 2 S: 10 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
53
C201H357N91O70S1
5200.67
12.83
+13
17.03
-1.515
Evidence Records 25 records
Evidence 1 Activity

Activity

MIC
Antibacterial
9.4 µM

Target

A. hydrophila

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against two Gram-negative fish pathogens A. salmonicida and A. hydrophila (MIC 9.4 uM) as well as P. aeruginosa IS 1411 (MIC 1.17 uM), P. aeruginosa ATCC 27853 (MIC 4.7 uM), E.
Evidence 2 Activity

Activity

MIC
Antibacterial
1.17 µM

Target

Pseudomonas aeruginosa IS 1411

Source & Reference

dbAMP

Other

two Gram-negative fish pathogens A. salmonicida and A. hydrophila (MIC 9.4 uM) as well as P. aeruginosa IS 1411 (MIC 1.17 uM), P. aeruginosa ATCC 27853 (MIC 4.7 uM), E. coli ATCC 25922 (MIC 2.34 uM), E. coli IS 1342
Evidence 3 Activity

Activity

MIC
Antibacterial
4.7 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP

Other

almonicida and A. hydrophila (MIC 9.4 uM) as well as P. aeruginosa IS 1411 (MIC 1.17 uM), P. aeruginosa ATCC 27853 (MIC 4.7 uM), E. coli ATCC 25922 (MIC 2.34 uM), E. coli IS 1342 (MIC 4.7 uM), K. pneumoniae IS 1373 (1
Evidence 4 Activity

Activity

MIC
Antibacterial
2.34 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP

Other

M) as well as P. aeruginosa IS 1411 (MIC 1.17 uM), P. aeruginosa ATCC 27853 (MIC 4.7 uM), E. coli ATCC 25922 (MIC 2.34 uM), E. coli IS 1342 (MIC 4.7 uM), K. pneumoniae IS 1373 (18.8 uM), A. baumannii (MIC 4.7 uM)
Evidence 5 Activity

Activity

MIC
Antibacterial
4.7 µM

Target

Escherichia coli IS 1342

Source & Reference

dbAMP

Other

1 (MIC 1.17 uM), P. aeruginosa ATCC 27853 (MIC 4.7 uM), E. coli ATCC 25922 (MIC 2.34 uM), E. coli IS 1342 (MIC 4.7 uM), K. pneumoniae IS 1373 (18.8 uM), A. baumannii (MIC 4.7 uM), P. mirabilis (MIC 18 uM), A.
Evidence 6 Activity

Activity

MIC
Antibacterial
4.7 µM

Target

A. baumannii

Source & Reference

dbAMP

Other

ATCC 25922 (MIC 2.34 uM), E. coli IS 1342 (MIC 4.7 uM), K. pneumoniae IS 1373 (18.8 uM), A. baumannii (MIC 4.7 uM), P. mirabilis (MIC 18 uM), A. sobria (MIC 18.8 uM), Gram-positive S. aureus ATCC 2592 (MI
Evidence 7 Activity

Activity

MIC
Antibacterial
18 µM

Target

P. mirabilis

Source & Reference

dbAMP

Other

E. coli IS 1342 (MIC 4.7 uM), K. pneumoniae IS 1373 (18.8 uM), A. baumannii (MIC 4.7 uM), P. mirabilis (MIC 18 uM), A. sobria (MIC 18.8 uM), Gram-positive S. aureus ATCC 2592 (MIC 11-45 uM), E. faecium (M
Evidence 8 Activity

Activity

MIC
Antibacterial
18.8 µM

Target

A. sobria

Source & Reference

dbAMP

Other

M), K. pneumoniae IS 1373 (18.8 uM), A. baumannii (MIC 4.7 uM), P. mirabilis (MIC 18 uM), A. sobria (MIC 18.8 uM), Gram-positive S. aureus ATCC 2592 (MIC 11-45 uM), E. faecium (MIC 11.4 uM), and fungi S.
Evidence 9 Activity

Activity

MIC
Antibacterial
11-45 µM

Target

Staphylococcus aureus ATCC 2592

Source & Reference

dbAMP

Other

baumannii (MIC 4.7 uM), P. mirabilis (MIC 18 uM), A. sobria (MIC 18.8 uM), Gram-positive S. aureus ATCC 2592 (MIC 11-45 uM), E. faecium (MIC 11.4 uM), and fungi S. mould (11-22 uM), C. albicans ATCC 2002 (MIC 2.3
Evidence 10 Activity

Activity

MIC
Antibacterial
11.4 µM

Target

E. faecium

Source & Reference

dbAMP

Other

s (MIC 18 uM), A. sobria (MIC 18.8 uM), Gram-positive S. aureus ATCC 2592 (MIC 11-45 uM), E. faecium (MIC 11.4 uM), and fungi S. mould (11-22 uM), C. albicans ATCC 2002 (MIC 2.3 uM), and C. glabrata IS 09
Evidence 11 Activity

Activity

MIC
Antibacterial
2.3 µM

Target

Candida albicans ATCC 2002

Source & Reference

dbAMP

Other

aureus ATCC 2592 (MIC 11-45 uM), E. faecium (MIC 11.4 uM), and fungi S. mould (11-22 uM), C. albicans ATCC 2002 (MIC 2.3 uM), and C. glabrata IS 0902 (MIC 9.4 uM).
Evidence 12 Activity

Activity

MIC
Antibacterial
9.4 µM

Target

C. glabrata IS 0902

Source & Reference

dbAMP

Other

ium (MIC 11.4 uM), and fungi S. mould (11-22 uM), C. albicans ATCC 2002 (MIC 2.3 uM), and C. glabrata IS 0902 (MIC 9.4 uM).
Evidence 13 Activity

Activity

MIC
Antifungal
9.4 µM

Target

A. hydrophila

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against two Gram-negative fish pathogens A. salmonicida and A. hydrophila (MIC 9.4 uM) as well as P. aeruginosa IS 1411 (MIC 1.17 uM), P. aeruginosa ATCC 27853 (MIC 4.7 uM), E.
Evidence 14 Activity

Activity

MIC
Antifungal
1.17 µM

Target

Pseudomonas aeruginosa IS 1411

Source & Reference

dbAMP CAFPdb Antifungipept

Other

two Gram-negative fish pathogens A. salmonicida and A. hydrophila (MIC 9.4 uM) as well as P. aeruginosa IS 1411 (MIC 1.17 uM), P. aeruginosa ATCC 27853 (MIC 4.7 uM), E. coli ATCC 25922 (MIC 2.34 uM), E. coli IS 1342
Evidence 15 Activity

Activity

MIC
Antifungal
4.7 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP CAFPdb Antifungipept

Other

almonicida and A. hydrophila (MIC 9.4 uM) as well as P. aeruginosa IS 1411 (MIC 1.17 uM), P. aeruginosa ATCC 27853 (MIC 4.7 uM), E. coli ATCC 25922 (MIC 2.34 uM), E. coli IS 1342 (MIC 4.7 uM), K. pneumoniae IS 1373 (1
Evidence 16 Activity

Activity

MIC
Antifungal
2.34 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

M) as well as P. aeruginosa IS 1411 (MIC 1.17 uM), P. aeruginosa ATCC 27853 (MIC 4.7 uM), E. coli ATCC 25922 (MIC 2.34 uM), E. coli IS 1342 (MIC 4.7 uM), K. pneumoniae IS 1373 (18.8 uM), A. baumannii (MIC 4.7 uM)
Evidence 17 Activity

Activity

MIC
Antifungal
4.7 µM

Target

Escherichia coli IS 1342

Source & Reference

dbAMP CAFPdb Antifungipept

Other

1 (MIC 1.17 uM), P. aeruginosa ATCC 27853 (MIC 4.7 uM), E. coli ATCC 25922 (MIC 2.34 uM), E. coli IS 1342 (MIC 4.7 uM), K. pneumoniae IS 1373 (18.8 uM), A. baumannii (MIC 4.7 uM), P. mirabilis (MIC 18 uM), A.
Evidence 18 Activity

Activity

MIC
Antifungal
4.7 µM

Target

A. baumannii

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ATCC 25922 (MIC 2.34 uM), E. coli IS 1342 (MIC 4.7 uM), K. pneumoniae IS 1373 (18.8 uM), A. baumannii (MIC 4.7 uM), P. mirabilis (MIC 18 uM), A. sobria (MIC 18.8 uM), Gram-positive S. aureus ATCC 2592 (MI
Evidence 19 Activity

Activity

MIC
Antifungal
18 µM

Target

P. mirabilis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

E. coli IS 1342 (MIC 4.7 uM), K. pneumoniae IS 1373 (18.8 uM), A. baumannii (MIC 4.7 uM), P. mirabilis (MIC 18 uM), A. sobria (MIC 18.8 uM), Gram-positive S. aureus ATCC 2592 (MIC 11-45 uM), E. faecium (M
Evidence 20 Activity

Activity

MIC
Antifungal
18.8 µM

Target

A. sobria

Source & Reference

dbAMP CAFPdb Antifungipept

Other

M), K. pneumoniae IS 1373 (18.8 uM), A. baumannii (MIC 4.7 uM), P. mirabilis (MIC 18 uM), A. sobria (MIC 18.8 uM), Gram-positive S. aureus ATCC 2592 (MIC 11-45 uM), E. faecium (MIC 11.4 uM), and fungi S.
Evidence 21 Activity

Activity

MIC
Antifungal
11-45 µM

Target

Staphylococcus aureus ATCC 2592

Source & Reference

dbAMP CAFPdb Antifungipept

Other

baumannii (MIC 4.7 uM), P. mirabilis (MIC 18 uM), A. sobria (MIC 18.8 uM), Gram-positive S. aureus ATCC 2592 (MIC 11-45 uM), E. faecium (MIC 11.4 uM), and fungi S. mould (11-22 uM), C. albicans ATCC 2002 (MIC 2.3
Evidence 22 Activity

Activity

MIC
Antifungal
11.4 µM

Target

E. faecium

Source & Reference

dbAMP CAFPdb Antifungipept

Other

s (MIC 18 uM), A. sobria (MIC 18.8 uM), Gram-positive S. aureus ATCC 2592 (MIC 11-45 uM), E. faecium (MIC 11.4 uM), and fungi S. mould (11-22 uM), C. albicans ATCC 2002 (MIC 2.3 uM), and C. glabrata IS 09
Evidence 23 Activity

Activity

MIC
Antifungal
2.3 µM

Target

Candida albicans ATCC 2002

Source & Reference

dbAMP CAFPdb Antifungipept

Other

aureus ATCC 2592 (MIC 11-45 uM), E. faecium (MIC 11.4 uM), and fungi S. mould (11-22 uM), C. albicans ATCC 2002 (MIC 2.3 uM), and C. glabrata IS 0902 (MIC 9.4 uM).
Evidence 24 Activity

Activity

MIC
Antifungal
9.4 µM

Target

C. glabrata IS 0902

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ium (MIC 11.4 uM), and fungi S. mould (11-22 uM), C. albicans ATCC 2002 (MIC 2.3 uM), and C. glabrata IS 0902 (MIC 9.4 uM).
Evidence 25 Activity

Activity

7% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
7% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structural and functional characterization of CATH_BRALE, the defense molecule in the ancient salmonoid, Brachymystax lenok. | Fish Shellfish Immunol | 2013