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Peptide record

TPDB14943

Antibacterial Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
133 amino acids
Basic Information
3D PDB MODEL
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TPDB14943
Antibacterial Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia Antifungipept dbAMP 3.0 i2APP APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 133-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from dbAMP, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
RPPQFTRAQWFAIQHISLNPPRCTIAMRAINNYRWRCKNQNTFLRTTFANVVNVCGNQSIRCPHNRTLNNCHRSRFRVPLLHCDLINPGAQNISNCTYADRPGRRFYVVACDNRDPRDSPRYPVVPVHLDTTI
Physicochemical Analysis
C675H1059N221O185S9
E
R
15518.74
10.67
24
6
45
+13
21.35
-0.598
69.62
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
17460
112.51
47
Residue Composition
number
8
A
18
R
15
N
6
D
8
C
0
E
6
Q
3
G
5
H
8
I
7
L
1
K
1
M
6
F
12
P
5
S
9
T
2
W
4
Y
9
V
Amino Acid Distribution
A: 8 R: 18 N: 15 D: 6 C: 8 E: 0 Q: 6 G: 3 H: 5 I: 8 L: 7 K: 1 M: 1 F: 6 P: 12 S: 5 T: 9 W: 2 Y: 4 V: 9
Chemical Descriptors
133
C675H1059N221O185S9
15518.74
10.67
+13
21.35
-0.598
Evidence Records 7 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Has ribonuclease activity. Active against parasites (see the ref). 500 nM rhECP reduced infectivity of extracellular virions of the single-stranded RNA virus, respiratory syncytial virus, group B (RSV-B) approximately 6 fold ( Domachowske JB et al. 1998 ). Also active against M. vaccae ( Boix E et al., 2008 ). It binds to LPS. RNase 3 has a unique bacteria-agglutinating activity.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Has ribonuclease activity. Active against parasites (see the ref). 500 nM rhECP reduced infectivity of extracellular virions of the single-stranded RNA virus, respiratory syncytial virus, group B (RSV-B) approximately 6 fold ( Domachowske JB et al. 1998 ). Also active against M. vaccae ( Boix E et al., 2008 ). It binds to LPS. RNase 3 has a unique bacteria-agglutinating activity.
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
Has ribonuclease activity. Active against parasites (see the ref). 500 nM rhECP reduced infectivity of extracellular virions of the single-stranded RNA virus, respiratory syncytial virus, group B (RSV-B) approximately 6 fold ( Domachowske JB et al. 1998 ). Also active against M. vaccae ( Boix E et al., 2008 ). It binds to LPS. RNase 3 has a unique bacteria-agglutinating activity.
Evidence 4 Activity

Activity

Antiviral

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
Has ribonuclease activity. Active against parasites (see the ref). 500 nM rhECP reduced infectivity of extracellular virions of the single-stranded RNA virus, respiratory syncytial virus, group B (RSV-B) approximately 6 fold ( Domachowske JB et al. 1998 ). Also active against M. vaccae ( Boix E et al., 2008 ). It binds to LPS. RNase 3 has a unique bacteria-agglutinating activity.
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
>25 µM
Hemolytic Cytotoxic
50% Hemolysis | >25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Refining the eosinophil cationic protein antibacterial pharmacophore by rational structure minimization. | J Med Chem | 2011
Evidence 6 Activity

Activity

50% Hemolysis
Toxicity
>20 µM
Hemolytic Cytotoxic
50% Hemolysis | >20 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Insights into the Antimicrobial Mechanism of Action of Human RNase6: Structural Determinants for Bacterial Cell Agglutination and Membrane Permeation. | Int J Mol Sci | 2016
Evidence 7 Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.