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Peptide record

TPDB14894

Antibacterial Anticancer Antifungal Antiparasitic standard

62 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB14894

Activity

Antibacterial Anticancer Antifungal Antiparasitic

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

dbAMP DRAMP Peptipedia Antifungipept CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 62-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.

Sequence

QVYKGGYTRPIPRPPPFVRPLPGGPIGPYNGCPVSCRGISFSQARSCCSRLGRCCHVGKGYS

FASTA

>TPDB14894|Antibacterial;Anticancer;Antifungal;Antiparasitic|length=62
QVYKGGYTRPIPRPPPFVRPLPGGPIGPYNGCPVSCRGISFSQARSCCSRLGRCCHVGKGYS

Formula C291H456N90O77S6

Absent Amino Acids DEMW

Common Amino Acids GP

Mass 6639.74

PI 10.03

Basic Residues 10

Acidic Residues 0

Hydrophobic Residues 16

Net Charge +9

Boman Index 6.31

Hydrophobicity -0.377

Aliphatic Index 51.77

Half Life

Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour

Extinction Coefficient Cystines 6335

Absorbance 280nm 95.41

Polar Residues 20

number

Amino Acid Distribution

A: 1 R: 7 N: 1 D: 0 C: 6 E: 0 Q: 2 G: 10 H: 1 I: 3 L: 2 K: 2 M: 0 F: 2 P: 10 S: 6 T: 1 W: 0 Y: 4 V: 4

Length

Formula

C291H456N90O77S6

Mass

6639.74

10.03

Net Charge

Boman Index

6.31

Hydrophobicity

-0.377

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.6-2.5 µM

Target

Target Organism M. luteus

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

active against M. luteus (MIC 0.6-2.5 uM), E. coli 363 (MIC 2.5-10 uM), F. oxysporum (MIC 5-10 uM), S.cerevisiae TGY (MIC >100 uM).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.5-10 µM

Target

Target Organism Escherichia coli 363

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against M. luteus (MIC 0.6-2.5 uM), E. coli 363 (MIC 2.5-10 uM), F. oxysporum (MIC 5-10 uM), S.cerevisiae TGY (MIC >100 uM). Warning: nonstandard assays

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 5-10 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against M. luteus (MIC 0.6-2.5 uM), E. coli 363 (MIC 2.5-10 uM), F. oxysporum (MIC 5-10 uM), S.cerevisiae TGY (MIC >100 uM). Warning: nonstandard assays against bacteria in 1% bacto

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µM

Target

Target Organism S.cerevisiae TGY

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

inst M. luteus (MIC 0.6-2.5 uM), E. coli 363 (MIC 2.5-10 uM), F. oxysporum (MIC 5-10 uM), S.cerevisiae TGY (MIC >100 uM). Warning: nonstandard assays against bacteria in 1% bactotryptone.

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.6-2.5 µM

Target

Target Organism M. luteus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

active against M. luteus (MIC 0.6-2.5 uM), E. coli 363 (MIC 2.5-10 uM), F. oxysporum (MIC 5-10 uM), S.cerevisiae TGY (MIC >100 uM).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2.5-10 µM

Target

Target Organism Escherichia coli 363

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

active against M. luteus (MIC 0.6-2.5 uM), E. coli 363 (MIC 2.5-10 uM), F. oxysporum (MIC 5-10 uM), S.cerevisiae TGY (MIC >100 uM). Warning: nonstandard assays

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 5-10 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

active against M. luteus (MIC 0.6-2.5 uM), E. coli 363 (MIC 2.5-10 uM), F. oxysporum (MIC 5-10 uM), S.cerevisiae TGY (MIC >100 uM). Warning: nonstandard assays against bacteria in 1% bacto

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µM

Target

Target Organism S.cerevisiae TGY

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

inst M. luteus (MIC 0.6-2.5 uM), E. coli 363 (MIC 2.5-10 uM), F. oxysporum (MIC 5-10 uM), S.cerevisiae TGY (MIC >100 uM). Warning: nonstandard assays against bacteria in 1% bactotryptone.

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 0.6-2.5 µM

Target

Target Organism M. luteus

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

active against M. luteus (MIC 0.6-2.5 uM), E. coli 363 (MIC 2.5-10 uM), F. oxysporum (MIC 5-10 uM), S.cerevisiae TGY (MIC >100 uM).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2.5-10 µM

Target

Target Organism Escherichia coli 363

Source & Reference

Database Source DRAMP

Other

Evidence Text

active against M. luteus (MIC 0.6-2.5 uM), E. coli 363 (MIC 2.5-10 uM), F. oxysporum (MIC 5-10 uM), S.cerevisiae TGY (MIC >100 uM). Warning: nonstandard assays

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 5-10 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source DRAMP

Other

Evidence Text

active against M. luteus (MIC 0.6-2.5 uM), E. coli 363 (MIC 2.5-10 uM), F. oxysporum (MIC 5-10 uM), S.cerevisiae TGY (MIC >100 uM). Warning: nonstandard assays against bacteria in 1% bacto

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µM

Target

Target Organism S.cerevisiae TGY

Source & Reference

Database Source DRAMP

Other

Evidence Text

inst M. luteus (MIC 0.6-2.5 uM), E. coli 363 (MIC 2.5-10 uM), F. oxysporum (MIC 5-10 uM), S.cerevisiae TGY (MIC >100 uM). Warning: nonstandard assays against bacteria in 1% bactotryptone.