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Peptide record

TPDB14860

Antibacterial Anticancer Antifungal Antiparasitic Antiviral standard
60 amino acids
Basic Information
3D PDB MODEL
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TPDB14860
Antibacterial Anticancer Antifungal Antiparasitic Antiviral
Anti-infective peptides Cancer-related peptides
dbAMP DRAMP Peptipedia Antifungipept
standard
No
A 60-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
QIVDCWETWSRCTKWSQGGTGTLWKSCNDRCKELGRKRGQCEEKPSRCPLSKKAWTCICY
Physicochemical Analysis
C300H471N91O88S8
HMF
C
7017.08
8.73
12
6
13
+6
11.47
-0.948
39.00
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
29490
420.26
23
Residue Composition
number
1
A
5
R
1
N
2
D
8
C
4
E
3
Q
5
G
0
H
2
I
3
L
7
K
0
M
0
F
2
P
5
S
5
T
5
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 5 N: 1 D: 2 C: 8 E: 4 Q: 3 G: 5 H: 0 I: 2 L: 3 K: 7 M: 0 F: 0 P: 2 S: 5 T: 5 W: 5 Y: 1 V: 1
Chemical Descriptors
60
C300H471N91O88S8
7017.08
8.73
+6
11.47
-0.948
Evidence Records 4 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
LD90: 90% lethal dose. active against Gram- A. baumannii ATCC 19606 (LD90 1.8 uM), C. freundii NCTC 9750 or C7 (LD90 0.5-0.9 uM), E. cloacae Va11263/03 or Va12270/03 (LD90 0.5-0.9 uM), E. coli ATCC 25922 or Co 86 ESBL (LD90 0.2-0.9 uM), K. pneumoniae ATCC 13883 or ATCC 700603 ESBL (LD90 0.5-0.9 uM), K. oxytoca ATCC 13182 or ESBL 33 (LD90 0.5-0.9 uM), P. mirabilis ATCC 21100 (LD90 0.9 uM), P. vulgaris ATCC 13315 (LD90 3.6 uM), P-rettgeri NCTC 7475 (LD90 >14.3 uM), P. aeruginosa NCTC 11446 (LD90 14.3 uM), S. typhimurium 10003442 or 10003630 (LD90 0.5 uM), S. marcescens Mero060/148 or Mero103/013 or NCTC 10211 (LD90 1.8-14.3 uM), Y. enterocolitca NCTC 11176 (LD90 0.2 uM), Gram+ S-aureus ATCC 6538 or MRSA (LD90 >14.3 uM), S. hemolyticus ATCC 29970 (LD90 0.9 uM), E. faecalis ATCC 51299 anti-VRE (LD90 7.1 uM), and S. pyogenes ATCC 12344 (LD90 7.1 uM).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
LD90: 90% lethal dose. active against Gram- A. baumannii ATCC 19606 (LD90 1.8 uM), C. freundii NCTC 9750 or C7 (LD90 0.5-0.9 uM), E. cloacae Va11263/03 or Va12270/03 (LD90 0.5-0.9 uM), E. coli ATCC 25922 or Co 86 ESBL (LD90 0.2-0.9 uM), K. pneumoniae ATCC 13883 or ATCC 700603 ESBL (LD90 0.5-0.9 uM), K. oxytoca ATCC 13182 or ESBL 33 (LD90 0.5-0.9 uM), P. mirabilis ATCC 21100 (LD90 0.9 uM), P. vulgaris ATCC 13315 (LD90 3.6 uM), P-rettgeri NCTC 7475 (LD90 >14.3 uM), P. aeruginosa NCTC 11446 (LD90 14.3 uM), S. typhimurium 10003442 or 10003630 (LD90 0.5 uM), S. marcescens Mero060/148 or Mero103/013 or NCTC 10211 (LD90 1.8-14.3 uM), Y. enterocolitca NCTC 11176 (LD90 0.2 uM), Gram+ S-aureus ATCC 6538 or MRSA (LD90 >14.3 uM), S. hemolyticus ATCC 29970 (LD90 0.9 uM), E. faecalis ATCC 51299 anti-VRE (LD90 7.1 uM), and S. pyogenes ATCC 12344 (LD90 7.1 uM).
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

DRAMP

Other

LD90: 90% lethal dose. active against Gram- A. baumannii ATCC 19606 (LD90 1.8 uM), C. freundii NCTC 9750 or C7 (LD90 0.5-0.9 uM), E. cloacae Va11263/03 or Va12270/03 (LD90 0.5-0.9 uM), E. coli ATCC 25922 or Co 86 ESBL (LD90 0.2-0.9 uM), K. pneumoniae ATCC 13883 or ATCC 700603 ESBL (LD90 0.5-0.9 uM), K. oxytoca ATCC 13182 or ESBL 33 (LD90 0.5-0.9 uM), P. mirabilis ATCC 21100 (LD90 0.9 uM), P. vulgaris ATCC 13315 (LD90 3.6 uM), P-rettgeri NCTC 7475 (LD90 >14.3 uM), P. aeruginosa NCTC 11446 (LD90 14.3 uM), S. typhimurium 10003442 or 10003630 (LD90 0.5 uM), S. marcescens Mero060/148 or Mero103/013 or NCTC 10211 (LD90 1.8-14.3 uM), Y. enterocolitca NCTC 11176 (LD90 0.2 uM), Gram+ S-aureus ATCC 6538 or MRSA (LD90 >14.3 uM), S. hemolyticus ATCC 29970 (LD90 0.9 uM), E. faecalis ATCC 51299 anti-VRE (LD90 7.1 uM), and S. pyogenes ATCC 12344 (LD90 7.1 uM).
Evidence 4 Activity

Activity

Antiviral

Source & Reference

DRAMP

Other

LD90: 90% lethal dose. active against Gram- A. baumannii ATCC 19606 (LD90 1.8 uM), C. freundii NCTC 9750 or C7 (LD90 0.5-0.9 uM), E. cloacae Va11263/03 or Va12270/03 (LD90 0.5-0.9 uM), E. coli ATCC 25922 or Co 86 ESBL (LD90 0.2-0.9 uM), K. pneumoniae ATCC 13883 or ATCC 700603 ESBL (LD90 0.5-0.9 uM), K. oxytoca ATCC 13182 or ESBL 33 (LD90 0.5-0.9 uM), P. mirabilis ATCC 21100 (LD90 0.9 uM), P. vulgaris ATCC 13315 (LD90 3.6 uM), P-rettgeri NCTC 7475 (LD90 >14.3 uM), P. aeruginosa NCTC 11446 (LD90 14.3 uM), S. typhimurium 10003442 or 10003630 (LD90 0.5 uM), S. marcescens Mero060/148 or Mero103/013 or NCTC 10211 (LD90 1.8-14.3 uM), Y. enterocolitca NCTC 11176 (LD90 0.2 uM), Gram+ S-aureus ATCC 6538 or MRSA (LD90 >14.3 uM), S. hemolyticus ATCC 29970 (LD90 0.9 uM), E. faecalis ATCC 51299 anti-VRE (LD90 7.1 uM), and S. pyogenes ATCC 12344 (LD90 7.1 uM).