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Peptide record

TPDB14845

Antibacterial Antifungal standard
125 amino acids
Basic Information
3D PDB MODEL
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TPDB14845
Antibacterial Antifungal
Anti-infective peptides
dbAMP Peptipedia Antifungipept CAFPdb
standard
No
A 125-aa standard-residue multi-activity (Antibacterial and Antifungal) peptide sequence curated from dbAMP, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
QDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGPTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRPRP
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C620H976N202O181S7
R
14380.23
10.14
27
10
33
+11
2.99
-0.984
53.04
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
11835
0.82
41
Residue Composition
number
5
A
14
R
9
N
6
D
6
C
4
E
6
Q
8
G
6
H
7
I
5
L
7
K
1
M
5
F
10
P
9
S
7
T
1
W
4
Y
5
V
Amino Acid Distribution
A: 5 R: 14 N: 9 D: 6 C: 6 E: 4 Q: 6 G: 8 H: 6 I: 7 L: 5 K: 7 M: 1 F: 5 P: 10 S: 9 T: 7 W: 1 Y: 4 V: 5
Chemical Descriptors
125 reviewed residue count
C620H976N202O181S7 sequence-only estimate (linear, free termini)
14380.23 sequence-only estimate (linear, free termini)
10.14 sequence-only estimate (linear, free termini)
+11 sequence-only estimate (linear, free termini)
2.99 sequence-only estimate (linear, free termini)
-0.984 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Initially implicated in angiogenesis (angiogenic) and human cancer with weak RNase activity (ribonuclease activity). It is also established that this peptide is active against C. albicans and S. pneumoniae. Another paper: this peptide also specifically inhibited M. tuberculosis (Mtb, anti-TB).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Initially implicated in angiogenesis (angiogenic) and human cancer with weak RNase activity (ribonuclease activity). It is also established that this peptide is active against C. albicans and S. pneumoniae. Another paper: this peptide also specifically inhibited M. tuberculosis (Mtb, anti-TB).