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Peptide record

TPDB14749

Antibacterial Antifungal Toxicity standard
74 amino acids
Basic Information
3D PDB MODEL
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TPDB14749
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb
standard
No
A 74-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLR
Physicochemical Analysis
C374H623N103O116S1
CW
L
8450.74
7.67
12
11
26
+0
25.78
-0.492
102.70
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
17.63
19
Residue Composition
number
2
A
4
R
2
N
5
D
0
C
6
E
6
Q
4
G
1
H
7
I
9
L
7
K
1
M
2
F
3
P
3
S
7
T
0
W
1
Y
4
V
Amino Acid Distribution
A: 2 R: 4 N: 2 D: 5 C: 0 E: 6 Q: 6 G: 4 H: 1 I: 7 L: 9 K: 7 M: 1 F: 2 P: 3 S: 3 T: 7 W: 0 Y: 1 V: 4
Chemical Descriptors
74
C374H623N103O116S1
8450.74
7.67
+0
25.78
-0.492
Evidence Records 5 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Antimicrobial minimal effective concentration (MEC): Active against B. subtilis KCTC1021 (0.4 u), S. aureus RM4220 (4.7 uM), E. coli D31 (0.2 uM), E. coli ML35p (1.4 uM), P. aeruginosa KCTC2004 (0.6 uM), S. flexneri KCTC2517 (0.7 uM), S. sonnei KCTC2009 (1.2 uM), fish pathogens A. hydrophila KCTC2358 (0.7 uM), S. iniae FP5229 (0.9 uM), V. parahaemolyticus KCCM41664 (1.1 uM), and yeast C-albicans KCTC7965 (>80 ug/ml). It displayed bacteriostatic activity.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Antimicrobial minimal effective concentration (MEC): Active against B. subtilis KCTC1021 (0.4 u), S. aureus RM4220 (4.7 uM), E. coli D31 (0.2 uM), E. coli ML35p (1.4 uM), P. aeruginosa KCTC2004 (0.6 uM), S. flexneri KCTC2517 (0.7 uM), S. sonnei KCTC2009 (1.2 uM), fish pathogens A. hydrophila KCTC2358 (0.7 uM), S. iniae FP5229 (0.9 uM), V. parahaemolyticus KCCM41664 (1.1 uM), and yeast C-albicans KCTC7965 (>80 ug/ml). It displayed bacteriostatic activity.
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Purification and antimicrobial function of ubiquitin isolated from the gill of Pacific oyster, Crassostrea gigas. | Mol Immunol | 2013
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Hagfish erythrocytes

Target

Hagfish erythrocytes

Source & Reference

NA
DBAASP
Purification and antimicrobial function of ubiquitin isolated from the gill of Pacific oyster, Crassostrea gigas. | Mol Immunol | 2013
Evidence 5 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.22858580]Non-hemolytic against human red blood cells up to 100 µg/mL

Target

erythrocytes

Source & Reference

NA
DRAMP
Mol Immunol. 2013 Jan 53(1-2):88-98.