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Peptide record

TPDB14727

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
52 amino acids
Basic Information
3D PDB MODEL
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TPDB14727
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb AVPpred-BWR
standard
No
A 52-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
MLCKLSMFGAVLGVPACAIDCLPMGKTGGSCEGGVCGCRKLTFKILWDKKFG
Physicochemical Analysis
C240H392N62O63S9
NQHY
G
5442.67
8.58
7
3
21
+4
1.11
0.573
82.50
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5875
107.94
10
Residue Composition
number
3
A
1
R
0
N
2
D
6
C
1
E
0
Q
9
G
0
H
2
I
6
L
6
K
3
M
3
F
2
P
2
S
2
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 3 R: 1 N: 0 D: 2 C: 6 E: 1 Q: 0 G: 9 H: 0 I: 2 L: 6 K: 6 M: 3 F: 3 P: 2 S: 2 T: 2 W: 1 Y: 0 V: 3
Chemical Descriptors
52
C240H392N62O63S9
5442.67
8.58
+4
1.11
0.573
Evidence Records 6 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against tested strains (MIC: Gram-positive S. aureus 1.25 ug/ml B. cereus 25 Gram-negative E. coli 1.25 B. dysenteriae, 1.25 P. aeruginosa, 5 ug/ml and fungal C. albicans 1.25 ug/ml.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against tested strains (MIC: Gram-positive S. aureus 1.25 ug/ml B. cereus 25 Gram-negative E. coli 1.25 B. dysenteriae, 1.25 P. aeruginosa, 5 ug/ml and fungal C. albicans 1.25 ug/ml.
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

DRAMP

Other

Active against tested strains (MIC: Gram-positive S. aureus 1.25 ug/ml B. cereus 25 Gram-negative E. coli 1.25 B. dysenteriae, 1.25 P. aeruginosa, 5 ug/ml and fungal C. albicans 1.25 ug/ml.
Evidence 4 Activity

Activity

Antiviral

Source & Reference

DRAMP

Other

Active against tested strains (MIC: Gram-positive S. aureus 1.25 ug/ml B. cereus 25 Gram-negative E. coli 1.25 B. dysenteriae, 1.25 P. aeruginosa, 5 ug/ml and fungal C. albicans 1.25 ug/ml.
Evidence 5 Activity

Activity

7% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
7% Hemolysis | 200 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
A defensin-like antimicrobial peptide from the venoms of spider, Ornithoctonus hainana. | J Pept Sci | 2011
Evidence 6 Activity

Activity

% Hemolysis
Toxicity
7 %
Hemolytic
Hemolytic_activity: [Ref.21538709] It has little hemolytic activity, inducing 7% hemolysis at the concentration up to 200 µg/ml (about 36 µM).

Target

erythrocytes

Source & Reference

NA
DRAMP
J Pept Sci. 2011 Jul 17(7):540-544.