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Peptide record

TPDB14663

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
70 amino acids
Basic Information
3D PDB MODEL
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TPDB14663
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
dbAMP DRAMP Peptipedia Antifungipept
standard
No
A 70-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
MAKEFGIPAAVAGTVLNVVEAGGWVTTIVSILTAVGSGGLSLLAAAGRESIKAYLKKEIKKKGKRAVIAW
Physicochemical Analysis
C328H549N87O89S1
DCQH
A
7167.56
10.57
10
4
37
+6
6.96
0.539
117.14
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
12490
174.26
10
Residue Composition
number
12
A
2
R
1
N
0
D
0
C
4
E
0
Q
9
G
0
H
6
I
6
L
8
K
1
M
1
F
1
P
4
S
4
T
2
W
1
Y
8
V
Amino Acid Distribution
A: 12 R: 2 N: 1 D: 0 C: 0 E: 4 Q: 0 G: 9 H: 0 I: 6 L: 6 K: 8 M: 1 F: 1 P: 1 S: 4 T: 4 W: 2 Y: 1 V: 8
Chemical Descriptors
70
C328H549N87O89S1
7167.56
10.57
+6
6.96
0.539
Evidence Records 2 records
Evidence 1 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Murine macrophage cells J774.2

Target

Murine macrophage cells J774.2

Source & Reference

NA
DBAASP
Synergistic activity of AS-48 with ethambutol was observed on M. tuberculosis-infected macrophages | Antimicrob Agents Chemother | 2018
Evidence 2 Activity

Activity

65% Killing
Toxicity
128
Cytotoxic
65% Killing | 128 | target cell: Murine macrophage cells J774.2

Target

Murine macrophage cells J774.2

Source & Reference

NA
DBAASP
Synergistic activity of AS-48 with ethambutol was observed on M. tuberculosis-infected macrophages | Antimicrob Agents Chemother | 2018