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Peptide record

TPDB14651

Antibacterial Antifungal Hemolysis Toxicity standard
64 amino acids
Basic Information
3D PDB MODEL
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TPDB14651
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP DRAMP Peptipedia Antifungipept APD_complete HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 64-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
LTANLGISSYAAKKVIDIINTGSAVATIIALVTAVVGGGLITAGIVATAKSLIKKYGAKYAAAW
Physicochemical Analysis
C292H489N73O82
RCEQHMFP
A
6334.53
10.30
6
1
38
+5
-2.78
0.953
134.38
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
9970
157.39
15
Residue Composition
number
14
A
0
R
2
N
1
D
0
C
0
E
0
Q
7
G
0
H
9
I
5
L
6
K
0
M
0
F
0
P
4
S
6
T
1
W
3
Y
6
V
Amino Acid Distribution
A: 14 R: 0 N: 2 D: 1 C: 0 E: 0 Q: 0 G: 7 H: 0 I: 9 L: 5 K: 6 M: 0 F: 0 P: 0 S: 4 T: 6 W: 1 Y: 3 V: 6
Chemical Descriptors
64
C292H489N73O82
6334.53
10.30
+5
-2.78
0.953
Evidence Records 4 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.05-5.7 µM

Target

Staphylococcus epidermidis JCM 2414

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
1465, K. rhizophila NBRC 12708, L. innocua ATCC 33090, L. monocytogenes ATCC BAA-679, and S. epidermidis JCM 2414 (MIC 0.05-5.7 uM).
Evidence 2 Activity

Activity

MIC
Antifungal
0.05-5.7 µM

Target

Staphylococcus epidermidis JCM 2414

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
1465, K. rhizophila NBRC 12708, L. innocua ATCC 33090, L. monocytogenes ATCC BAA-679, and S. epidermidis JCM 2414 (MIC 0.05-5.7 uM).
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
6.9 µM
Hemolytic Cytotoxic
50% Hemolysis | 6.9 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification, Characterization, and Three-Dimensional Structure of the Novel Circular Bacteriocin, Enterocin NKR-5-3B, from Enterococcus faecium. | Biochemistry | 2015
Evidence 4 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.