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Peptide record

TPDB14648

Antibacterial Anticancer Antifungal Antiparasitic standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB14648
Antibacterial Anticancer Antifungal Antiparasitic
Anti-infective peptides Cancer-related peptides
dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF
standard
No
A 35-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
LRDLVCYCRTRGCKRREHMNGTCRKGHLMYTLCCR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C172H291N63O46S8
AQIFPSW
R
4234.08
9.64
11
2
9
+7
3.32
-0.683
52.86
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
3355
0.79
12
Residue Composition
number
0
A
7
R
1
N
1
D
6
C
1
E
0
Q
3
G
2
H
0
I
4
L
2
K
2
M
0
F
0
P
0
S
3
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 7 N: 1 D: 1 C: 6 E: 1 Q: 0 G: 3 H: 2 I: 0 L: 4 K: 2 M: 2 F: 0 P: 0 S: 0 T: 3 W: 0 Y: 2 V: 1
Chemical Descriptors
35 main sequence record
C172H291N63O46S8 sequence-only estimate (linear, free termini)
4234.08 sequence-only estimate (linear, free termini)
9.64 sequence-only estimate (linear, free termini)
+7 sequence-only estimate (linear, free termini)
3.32 sequence-only estimate (linear, free termini)
-0.683 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
killed 99.9% E. coli (9.8 ug/ml) and S. aureus (6.3 ug/ml) based on virtual colony count assays. This method exposed bacteria to peptides for 2 h in 10 mM phospahtate buffer before incubating in media for 12 h.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
killed 99.9% E. coli (9.8 ug/ml) and S. aureus (6.3 ug/ml) based on virtual colony count assays. This method exposed bacteria to peptides for 2 h in 10 mM phospahtate buffer before incubating in media for 12 h.
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

DRAMP

Other

killed 99.9% E. coli (9.8 ug/ml) and S. aureus (6.3 ug/ml) based on virtual colony count assays. This method exposed bacteria to peptides for 2 h in 10 mM phospahtate buffer before incubating in media for 12 h.