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Peptide record

TPDB14646

Vasostatin-1 Antibacterial Anticancer Antifungal Antiparasitic Neuropeptide standard
76 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB14646
Vasostatin-1
Antibacterial Anticancer Antifungal Antiparasitic Neuropeptide
Anti-infective peptides Cancer-related peptides Neuroactive peptides
dbAMP DRAMP Peptipedia Antifungipept CAFPdb
standard
No
A 76-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
LPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSKECFETLRGDERILSILRHQNLLKELQDLALQGAKERTHQQ
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C370H620N106O117S5
WY
L
8585.93
6.10
12
11
25
-1
2.04
-0.487
93.55
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
125
0.01
20
Residue Composition
number
2
A
4
R
3
N
4
D
2
C
7
E
5
Q
3
G
2
H
4
I
10
L
6
K
3
M
1
F
5
P
6
S
4
T
0
W
0
Y
5
V
Amino Acid Distribution
A: 2 R: 4 N: 3 D: 4 C: 2 E: 7 Q: 5 G: 3 H: 2 I: 4 L: 10 K: 6 M: 3 F: 1 P: 5 S: 6 T: 4 W: 0 Y: 0 V: 5
Chemical Descriptors
76 main sequence record
C370H620N106O117S5 sequence-only estimate (linear, free termini)
8585.93 sequence-only estimate (linear, free termini)
6.10 sequence-only estimate (linear, free termini)
-1 sequence-only estimate (linear, free termini)
2.04 sequence-only estimate (linear, free termini)
-0.487 sequence-only estimate (linear, free termini)
Evidence Records 13 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2 µM

Target

M. luteus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram-positive bacteria M. luteus (MIC 2 uM), B. megaterium (MIC 0.2 uM), Filamentous fungi N. crassa, A. fumigatus, A. brassicola, N.
Evidence 2 Activity

Activity

MIC
Antibacterial
0.2 µM

Target

B. megaterium

Source & Reference

dbAMP DRAMP

Other

Active against Gram-positive bacteria M. luteus (MIC 2 uM), B. megaterium (MIC 0.2 uM), Filamentous fungi N. crassa, A. fumigatus, A. brassicola, N. haematococca, F. culmorum,
Evidence 3 Activity

Activity

MIC
Antibacterial
1-10 µM

Target

T. mentagrophytes

Source & Reference

dbAMP DRAMP

Other

fungi N. crassa, A. fumigatus, A. brassicola, N. haematococca, F. culmorum, F. oxyporum, T. mentagrophytes (MIC 1-10 uM), Yeast cells S. cerevisiae, and C. albicans (MIC 10 uM). Activity against filamentous fun
Evidence 4 Activity

Activity

MIC
Antibacterial
10 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

F. culmorum, F. oxyporum, T. mentagrophytes (MIC 1-10 uM), Yeast cells S. cerevisiae, and C. albicans (MIC 10 uM). Activity against filamentous fungi (MIC 5-30 uM): N. crassa, A. fumigatus, A. brassicola
Evidence 5 Activity

Activity

MIC
Antifungal
2 µM

Target

M. luteus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram-positive bacteria M. luteus (MIC 2 uM), B. megaterium (MIC 0.2 uM), Filamentous fungi N. crassa, A. fumigatus, A. brassicola, N.
Evidence 6 Activity

Activity

MIC
Antifungal
0.2 µM

Target

B. megaterium

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram-positive bacteria M. luteus (MIC 2 uM), B. megaterium (MIC 0.2 uM), Filamentous fungi N. crassa, A. fumigatus, A. brassicola, N. haematococca, F. culmorum,
Evidence 7 Activity

Activity

MIC
Antifungal
1-10 µM

Target

T. mentagrophytes

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

fungi N. crassa, A. fumigatus, A. brassicola, N. haematococca, F. culmorum, F. oxyporum, T. mentagrophytes (MIC 1-10 uM), Yeast cells S. cerevisiae, and C. albicans (MIC 10 uM). Activity against filamentous fun
Evidence 8 Activity

Activity

MIC
Antifungal
10 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

F. culmorum, F. oxyporum, T. mentagrophytes (MIC 1-10 uM), Yeast cells S. cerevisiae, and C. albicans (MIC 10 uM). Activity against filamentous fungi (MIC 5-30 uM): N. crassa, A. fumigatus, A. brassicola
Evidence 9 Activity

Activity

MIC
Antiparasitic
2 µM

Target

M. luteus

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against Gram-positive bacteria M. luteus (MIC 2 uM), B. megaterium (MIC 0.2 uM), Filamentous fungi N. crassa, A. fumigatus, A. brassicola, N.
Evidence 10 Activity

Activity

MIC
Antiparasitic
0.2 µM

Target

B. megaterium

Source & Reference

DRAMP

Other

Active against Gram-positive bacteria M. luteus (MIC 2 uM), B. megaterium (MIC 0.2 uM), Filamentous fungi N. crassa, A. fumigatus, A. brassicola, N. haematococca, F. culmorum,
Evidence 11 Activity

Activity

MIC
Antiparasitic
1-10 µM

Target

T. mentagrophytes

Source & Reference

DRAMP

Other

fungi N. crassa, A. fumigatus, A. brassicola, N. haematococca, F. culmorum, F. oxyporum, T. mentagrophytes (MIC 1-10 uM), Yeast cells S. cerevisiae, and C. albicans (MIC 10 uM). Activity against filamentous fun
Evidence 12 Activity

Activity

MIC
Antiparasitic
10 µM

Target

Candida albicans

Source & Reference

DRAMP

Other

F. culmorum, F. oxyporum, T. mentagrophytes (MIC 1-10 uM), Yeast cells S. cerevisiae, and C. albicans (MIC 10 uM). Activity against filamentous fungi (MIC 5-30 uM): N. crassa, A. fumigatus, A. brassicola
Evidence 13 Activity

Activity

Neuropeptide

Source & Reference

NA
NeuroPepV2

Other

Bos taurus
Chromogranin/secretogranin
Additional Detail Fields 1 fields
Chromogranin/secretogranin