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Peptide record

TPDB14619

Antibacterial Anticancer Antifungal Antiparasitic Antiviral standard

74 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB14619

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

dbAMP DRAMP Peptipedia ACP740 _ACP240 Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 74-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.

Sequence

LCLDQKPEMEPFRKDAQQALEPSRQRRWLHRRCLSGRGFCRAICSIFEEPVRGNIDCYFGYNCCRRMFSHYRTS

FASTA

>TPDB14619|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral|length=74
LCLDQKPEMEPFRKDAQQALEPSRQRRWLHRRCLSGRGFCRAICSIFEEPVRGNIDCYFGYNCCRRMFSHYRTS

Formula C384H597N123O106S9

Absent Amino Acids

Common Amino Acids R

Mass 8921.27

PI 8.93

Basic Residues 16

Acidic Residues 8

Hydrophobic Residues 23

Net Charge +6

Boman Index 16.57

Hydrophobicity -0.774

Aliphatic Index 50.14

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 10345

Absorbance 280nm 115.96

Polar Residues 22

number

Amino Acid Distribution

A: 3 R: 12 N: 2 D: 3 C: 7 E: 5 Q: 4 G: 4 H: 2 I: 3 L: 5 K: 2 M: 2 F: 5 P: 4 S: 5 T: 1 W: 1 Y: 3 V: 1

Length

Formula

C384H597N123O106S9

Mass

8921.27

8.93

Net Charge

Boman Index

16.57

Hydrophobicity

-0.774

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.64-3.28 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Recombinant peptide displayed activity against both G+ S. aureus (MIC 1.64-3.28 uM), M-luteus (MIC >26.26 uM), Bacillus sp. (MIC 13.13-26.26 uM) and G- bacteria V. anguillar

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 13.13-26.26 µM

Target

Target Organism V. anguillarum

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

.64-3.28 uM), M-luteus (MIC >26.26 uM), Bacillus sp. (MIC 13.13-26.26 uM) and G- bacteria V. anguillarum (MIC 13.13-26.26 uM), E-cloacae (MIC >26.26 uM), V. ichthyoenteri (MIC 3.28-6.56 uM), P. putida (MIC 1.64-3.28

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.28-6.56 µM

Target

Target Organism V. ichthyoenteri

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

26.26 uM) and G- bacteria V. anguillarum (MIC 13.13-26.26 uM), E-cloacae (MIC >26.26 uM), V. ichthyoenteri (MIC 3.28-6.56 uM), P. putida (MIC 1.64-3.28 uM), P-mirabilis (MIC>26.26 uM), and Enterobacter sp. (MIC 13.1

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.64-3.28 µM

Target

Target Organism P. putida

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

rum (MIC 13.13-26.26 uM), E-cloacae (MIC >26.26 uM), V. ichthyoenteri (MIC 3.28-6.56 uM), P. putida (MIC 1.64-3.28 uM), P-mirabilis (MIC>26.26 uM), and Enterobacter sp. (MIC 13.13-26.26 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.64-3.28 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Recombinant peptide displayed activity against both G+ S. aureus (MIC 1.64-3.28 uM), M-luteus (MIC >26.26 uM), Bacillus sp. (MIC 13.13-26.26 uM) and G- bacteria V. anguillar

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 13.13-26.26 µM

Target

Target Organism V. anguillarum

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3.28-6.56 µM

Target

Target Organism V. ichthyoenteri

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.64-3.28 µM

Target

Target Organism P. putida

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

rum (MIC 13.13-26.26 uM), E-cloacae (MIC >26.26 uM), V. ichthyoenteri (MIC 3.28-6.56 uM), P. putida (MIC 1.64-3.28 uM), P-mirabilis (MIC>26.26 uM), and Enterobacter sp. (MIC 13.13-26.26 uM).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.64-3.28 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Recombinant peptide displayed activity against both G+ S. aureus (MIC 1.64-3.28 uM), M-luteus (MIC >26.26 uM), Bacillus sp. (MIC 13.13-26.26 uM) and G- bacteria V. anguillar

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 13.13-26.26 µM

Target

Target Organism V. anguillarum

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 3.28-6.56 µM

Target

Target Organism V. ichthyoenteri

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.64-3.28 µM

Target

Target Organism P. putida

Source & Reference

Database Source DRAMP

Other

Evidence Text

rum (MIC 13.13-26.26 uM), E-cloacae (MIC >26.26 uM), V. ichthyoenteri (MIC 3.28-6.56 uM), P. putida (MIC 1.64-3.28 uM), P-mirabilis (MIC>26.26 uM), and Enterobacter sp. (MIC 13.13-26.26 uM).

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 1.64-3.28 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets.

Evidence Text

Recombinant peptide displayed activity against both G+ S. aureus (MIC 1.64-3.28 uM), M-luteus (MIC >26.26 uM), Bacillus sp. (MIC 13.13-26.26 uM) and G- bacteria V. anguillar

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 13.13-26.26 µM

Target

Target Organism V. anguillarum

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 3.28-6.56 µM

Target

Target Organism V. ichthyoenteri

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 1.64-3.28 µM

Target

Target Organism P. putida

Source & Reference

Database Source DRAMP

Other

Evidence Text

rum (MIC 13.13-26.26 uM), E-cloacae (MIC >26.26 uM), V. ichthyoenteri (MIC 3.28-6.56 uM), P. putida (MIC 1.64-3.28 uM), P-mirabilis (MIC>26.26 uM), and Enterobacter sp. (MIC 13.13-26.26 uM).