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Peptide record

TPDB14583

Antibacterial Antifungal standard
128 amino acids
Basic Information
3D PDB MODEL
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TPDB14583
Antibacterial Antifungal
Anti-infective peptides
dbAMP Peptipedia Antifungipept
standard
No
A 128-aa standard natural multi-activity (Antibacterial and Antifungal) peptide sequence curated from dbAMP, Peptipedia, and Antifungipept, with an available 3D structural model.
Sequence
KVYDRCEFARILKKSGMDGYRGVSLANWVCLAKWESDFNTKAINHNVGSTDYGIFQINSRYWCNDGKTPKAVNACHISCKVLLDDDLSQDIECAKRVVRDPLGVKAWVAWRAHCQNKDVSQYIRGCKL
Physicochemical Analysis
C642H1003N187O185S9
K
14589.71
8.68
23
14
50
+6
21.88
-0.413
78.44
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
35450
242.98
36
Residue Composition
number
10
A
8
R
8
N
11
D
8
C
3
E
4
Q
8
G
3
H
7
I
8
L
12
K
1
M
3
F
2
P
8
S
3
T
5
W
5
Y
11
V
Amino Acid Distribution
A: 10 R: 8 N: 8 D: 11 C: 8 E: 3 Q: 4 G: 8 H: 3 I: 7 L: 8 K: 12 M: 1 F: 3 P: 2 S: 8 T: 3 W: 5 Y: 5 V: 11
Chemical Descriptors
128
C642H1003N187O185S9
14589.71
8.68
+6
21.88
-0.413
Evidence Records 2 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
This study shows activity against S. aureus ATCC 25923, E. coli ATCC 10798, E. coli ATCC 25922, and P. aeruginosa ATCC 15442. Trypsin digestion identified two active peptides: LP (seqeuence GVSLANWVCLAK) and SP (sequence AWVAWK against G- bacteria). Fusing SP with the native sequence enhanced the lysozyme activitiy.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
This study shows activity against S. aureus ATCC 25923, E. coli ATCC 10798, E. coli ATCC 25922, and P. aeruginosa ATCC 15442. Trypsin digestion identified two active peptides: LP (seqeuence GVSLANWVCLAK) and SP (sequence AWVAWK against G- bacteria). Fusing SP with the native sequence enhanced the lysozyme activitiy.