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Peptide record

TPDB14583

Antibacterial Antifungal standard
128 amino acids
Basic Information
3D PDB MODEL
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TPDB14583
Antibacterial Antifungal
Anti-infective peptides
dbAMP Peptipedia Antifungipept
standard
No
A 128-aa standard-residue multi-activity (Antibacterial and Antifungal) peptide sequence curated from dbAMP, Peptipedia, and Antifungipept, with an available 3D structural model.
Sequence
KVYDRCEFARILKKSGMDGYRGVSLANWVCLAKWESDFNTKAINHNVGSTDYGIFQINSRYWCNDGKTPKAVNACHISCKVLLDDDLSQDIECAKRVVRDPLGVKAWVAWRAHCQNKDVSQYIRGCKL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C642H1003N187O185S9
K
14589.71
8.68
23
14
50
+6
1.95
-0.413
78.44
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
35450
2.43
36
Residue Composition
number
10
A
8
R
8
N
11
D
8
C
3
E
4
Q
8
G
3
H
7
I
8
L
12
K
1
M
3
F
2
P
8
S
3
T
5
W
5
Y
11
V
Amino Acid Distribution
A: 10 R: 8 N: 8 D: 11 C: 8 E: 3 Q: 4 G: 8 H: 3 I: 7 L: 8 K: 12 M: 1 F: 3 P: 2 S: 8 T: 3 W: 5 Y: 5 V: 11
Chemical Descriptors
128 reviewed residue count
C642H1003N187O185S9 sequence-only estimate (linear, free termini)
14589.71 sequence-only estimate (linear, free termini)
8.68 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
1.95 sequence-only estimate (linear, free termini)
-0.413 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
This study shows activity against S. aureus ATCC 25923, E. coli ATCC 10798, E. coli ATCC 25922, and P. aeruginosa ATCC 15442. Trypsin digestion identified two active peptides: LP (seqeuence GVSLANWVCLAK) and SP (sequence AWVAWK against G- bacteria). Fusing SP with the native sequence enhanced the lysozyme activitiy.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
This study shows activity against S. aureus ATCC 25923, E. coli ATCC 10798, E. coli ATCC 25922, and P. aeruginosa ATCC 15442. Trypsin digestion identified two active peptides: LP (seqeuence GVSLANWVCLAK) and SP (sequence AWVAWK against G- bacteria). Fusing SP with the native sequence enhanced the lysozyme activitiy.