Back to search

Peptide record

TPDB14531

Antibacterial Anticancer Antifungal Antiparasitic standard
63 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB14531
Antibacterial Anticancer Antifungal Antiparasitic
Anti-infective peptides Cancer-related peptides
dbAMP DRAMP Peptipedia
standard
No
A 63-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, DRAMP, and Peptipedia, with an available 3D structural model.
Sequence
KRHILRCMGNSGICRASCKKNEQPYLYCRNCQSCCLQSYMRISISGKEENTDWSYEKQWPRLP
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C318H504N98O94S9
FV
CS
7492.64
8.89
12
5
17
+6
2.72
-0.924
51.11
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
17335
2.31
27
Residue Composition
number
1
A
6
R
4
N
1
D
7
C
4
E
4
Q
3
G
1
H
4
I
4
L
5
K
2
M
0
F
3
P
7
S
1
T
2
W
4
Y
0
V
Amino Acid Distribution
A: 1 R: 6 N: 4 D: 1 C: 7 E: 4 Q: 4 G: 3 H: 1 I: 4 L: 4 K: 5 M: 2 F: 0 P: 3 S: 7 T: 1 W: 2 Y: 4 V: 0
Chemical Descriptors
63 main sequence record
C318H504N98O94S9 sequence-only estimate (linear, free termini)
7492.64 sequence-only estimate (linear, free termini)
8.89 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
2.72 sequence-only estimate (linear, free termini)
-0.924 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against P. stercorea (~20% decrease at 12 ug/ml), S. mitis (~reduced ~15% at 12 ug/ml), S. Anginosus (reduced >20% at 12 ug/ml), and S. intermedius (reduced 10% at 12 ug/ml) but not P-aeruginosa or P-copri at 12 ug/ml. Notably, the defensin promoted growth at 3 ug/ml but inhibited growth at an elevated concentration.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against P. stercorea (~20% decrease at 12 ug/ml), S. mitis (~reduced ~15% at 12 ug/ml), S. Anginosus (reduced >20% at 12 ug/ml), and S. intermedius (reduced 10% at 12 ug/ml) but not P-aeruginosa or P-copri at 12 ug/ml. Notably, the defensin promoted growth at 3 ug/ml but inhibited growth at an elevated concentration.
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

DRAMP

Other

active against P. stercorea (~20% decrease at 12 ug/ml), S. mitis (~reduced ~15% at 12 ug/ml), S. Anginosus (reduced >20% at 12 ug/ml), and S. intermedius (reduced 10% at 12 ug/ml) but not P-aeruginosa or P-copri at 12 ug/ml. Notably, the defensin promoted growth at 3 ug/ml but inhibited growth at an elevated concentration.