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Peptide record

TPDB14523

Antibacterial Antifungal Toxicity standard
128 amino acids
Basic Information
3D PDB MODEL
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TPDB14523
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia Antifungipept CAFPdb
standard
No
A 128-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
KPKGMTSSQWFKIQHMQPSPQACNSAMKNINKHTKRCKDLNTFLHEPFSSVAATCQTPKIACKNGDKNCHQSHGAVSLTMCKLTSGKYPNCRYKEKRQNKSYVVACKPPQKKDSQQFHLVPVHLDRVL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C630H1013N191O180S12
K
14527.87
10.16
29
6
36
+16
2.17
-0.845
51.80
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
10470
0.72
47
Residue Composition
number
7
A
4
R
8
N
4
D
8
C
2
E
10
Q
4
G
7
H
3
I
7
L
18
K
4
M
4
F
9
P
11
S
7
T
1
W
3
Y
7
V
Amino Acid Distribution
A: 7 R: 4 N: 8 D: 4 C: 8 E: 2 Q: 10 G: 4 H: 7 I: 3 L: 7 K: 18 M: 4 F: 4 P: 9 S: 11 T: 7 W: 1 Y: 3 V: 7
Chemical Descriptors
128 reviewed residue count
C630H1013N191O180S12 sequence-only estimate (linear, free termini)
14527.87 sequence-only estimate (linear, free termini)
10.16 sequence-only estimate (linear, free termini)
+16 sequence-only estimate (linear, free termini)
2.17 sequence-only estimate (linear, free termini)
-0.845 sequence-only estimate (linear, free termini)
Evidence Records 4 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Has ribonuclease activity as well. Bacteria: Active against bacteria such as M. vaccae and yeast even at 4 oC. Recombinant RNase 7 exhibited antimicrobial activity against uropathogens (E. coli, P. aeruginosa, K. pneumonia, P. mirabilis, E. faecalis, and S. saprophyticus) at low micromolar concentrations by disrupting the microbial membrane as determined by atomic force microscopy ( Spencer JD et al., 2013 ). Viruses: it directly restricts herpes simplex virus type 1 (HSV-1) infection of human keratinocytes, possibly by promoting the degradation of incoming HSV-1 particles ( Zeitvogel et al., 2024 ).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Has ribonuclease activity as well. Bacteria: Active against bacteria such as M. vaccae and yeast even at 4 oC. Recombinant RNase 7 exhibited antimicrobial activity against uropathogens (E. coli, P. aeruginosa, K. pneumonia, P. mirabilis, E. faecalis, and S. saprophyticus) at low micromolar concentrations by disrupting the microbial membrane as determined by atomic force microscopy ( Spencer JD et al., 2013 ). Viruses: it directly restricts herpes simplex virus type 1 (HSV-1) infection of human keratinocytes, possibly by promoting the degradation of incoming HSV-1 particles ( Zeitvogel et al., 2024 ).
Evidence 3 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Ribonuclease 7, an antimicrobial peptide upregulated during infection, contributes to microbial defense of the human urinary tract. | Kidney Int | 2013
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Ribonuclease 7, an antimicrobial peptide upregulated during infection, contributes to microbial defense of the human urinary tract. | Kidney Int | 2013