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Peptide record

TPDB14522

Antibacterial Antifungal standard
127 amino acids
Basic Information
3D PDB MODEL
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TPDB14522
Antibacterial Antifungal
Anti-infective peptides
dbAMP Peptipedia Antifungipept CAFPdb
standard
No
A 127-aa standard-residue multi-activity (Antibacterial and Antifungal) peptide sequence curated from dbAMP, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
KPKDMTSSQWFKTQHVQPSPQACNSAMSIINKYTERCKDLNTFLHEPFSSVAITCQTPNIACKNSCKNCHQSHGPMSLTMGELTSGKYPNCRYKEKHLNTPYIVACDPPQQGDPGYPLVPVHLDKVV
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C619H967N173O187S12
P
14209.25
8.30
19
9
37
+4
1.70
-0.633
56.77
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
13450
0.95
49
Residue Composition
number
5
A
2
R
8
N
5
D
8
C
4
E
8
Q
5
G
6
H
5
I
7
L
11
K
4
M
3
F
13
P
11
S
9
T
1
W
5
Y
7
V
Amino Acid Distribution
A: 5 R: 2 N: 8 D: 5 C: 8 E: 4 Q: 8 G: 5 H: 6 I: 5 L: 7 K: 11 M: 4 F: 3 P: 13 S: 11 T: 9 W: 1 Y: 5 V: 7
Chemical Descriptors
127 reviewed residue count
C619H967N173O187S12 sequence-only estimate (linear, free termini)
14209.25 sequence-only estimate (linear, free termini)
8.30 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
1.70 sequence-only estimate (linear, free termini)
-0.633 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.2-0.9 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
nical isolate (anti-VRE) (MBC 0.4 uM), E-faecium clinical isolate (VRE) (MBC>7 uM), Gram- E. coli ATCC 25922 (MIC 0.2-0.9 uM), E. coli ATCC 35218 (MBC 0.2 uM), E. coli ATCC 11775 (MBC 0.4 uM), K. pneumoniae ATCC 138
Evidence 2 Activity

Activity

MIC
Antifungal
0.2-0.9 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
nical isolate (anti-VRE) (MBC 0.4 uM), E-faecium clinical isolate (VRE) (MBC>7 uM), Gram- E. coli ATCC 25922 (MIC 0.2-0.9 uM), E. coli ATCC 35218 (MBC 0.2 uM), E. coli ATCC 11775 (MBC 0.4 uM), K. pneumoniae ATCC 138