TPDB

3D PDB MODEL

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TPDB ID TPDB14522

Activity

Antibacterial Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

dbAMP Peptipedia Antifungipept CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 127-aa standard natural multi-activity (Antibacterial and Antifungal) peptide sequence curated from dbAMP, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.

Sequence

KPKDMTSSQWFKTQHVQPSPQACNSAMSIINKYTERCKDLNTFLHEPFSSVAITCQTPNIACKNSCKNCHQSHGPMSLTMGELTSGKYPNCRYKEKHLNTPYIVACDPPQQGDPGYPLVPVHLDKVV

FASTA

>TPDB14522|Antibacterial;Antifungal|length=127
KPKDMTSSQWFKTQHVQPSPQACNSAMSIINKYTERCKDLNTFLHEPFSSVAITCQTPNIACKNSCKNCHQSHGPMSLTMGELTSGKYPNCRYKEKHLNTPYIVACDPPQQGDPGYPLVPVHLDKVV

Formula C619H967N173O187S12

Absent Amino Acids

Common Amino Acids P

Mass 14209.25

PI 8.30

Basic Residues 19

Acidic Residues 9

Hydrophobic Residues 37

Net Charge +4

Boman Index 30.48

Hydrophobicity -0.633

Aliphatic Index 56.77

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 13450

Absorbance 280nm 94.66

Polar Residues 49

number

5

A

2

R

8

N

5

D

8

C

4

E

8

Q

5

G

6

H

5

I

7

L

11

K

4

M

3

F

13

P

11

S

9

T

1

W

5

Y

7

V

Amino Acid Distribution

A: 5 R: 2 N: 8 D: 5 C: 8 E: 4 Q: 8 G: 5 H: 6 I: 5 L: 7 K: 11 M: 4 F: 3 P: 13 S: 11 T: 9 W: 1 Y: 5 V: 7

Length

127

Formula

C619H967N173O187S12

Mass

14209.25

PI

8.30

Net Charge

+4

Boman Index

30.48

Hydrophobicity

-0.633

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.2-0.9 µM

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

nical isolate (anti-VRE) (MBC 0.4 uM), E-faecium clinical isolate (VRE) (MBC>7 uM), Gram- E. coli ATCC 25922 (MIC 0.2-0.9 uM), E. coli ATCC 35218 (MBC 0.2 uM), E. coli ATCC 11775 (MBC 0.4 uM), K. pneumoniae ATCC 138

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.2-0.9 µM

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

nical isolate (anti-VRE) (MBC 0.4 uM), E-faecium clinical isolate (VRE) (MBC>7 uM), Gram- E. coli ATCC 25922 (MIC 0.2-0.9 uM), E. coli ATCC 35218 (MBC 0.2 uM), E. coli ATCC 11775 (MBC 0.4 uM), K. pneumoniae ATCC 138