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Peptide record

TPDB14520

Antibacterial Anticancer Antifungal Antiparasitic standard
54 amino acids
Basic Information
3D PDB MODEL
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TPDB14520
Antibacterial Anticancer Antifungal Antiparasitic
Anti-infective peptides Cancer-related peptides
dbAMP DRAMP Peptipedia Antifp Antifungipept
standard
No
A 54-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
KLTFIQSTAAGDLYYNTNTHKYVYQQTQNAFGAAANTIVNGWMGGAAGGFGLHH
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C260H380N72O77S1
RCEP
AG
5778.37
9.31
5
1
24
+1
0.75
-0.244
61.67
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
11460
1.98
20
Residue Composition
number
8
A
0
R
5
N
1
D
0
C
0
E
4
Q
8
G
3
H
2
I
3
L
2
K
1
M
3
F
0
P
1
S
6
T
1
W
4
Y
2
V
Amino Acid Distribution
A: 8 R: 0 N: 5 D: 1 C: 0 E: 0 Q: 4 G: 8 H: 3 I: 2 L: 3 K: 2 M: 1 F: 3 P: 0 S: 1 T: 6 W: 1 Y: 4 V: 2
Chemical Descriptors
54 reviewed residue count
C260H380N72O77S1 sequence-only estimate (linear, free termini)
5778.37 sequence-only estimate (linear, free termini)
9.31 sequence-only estimate (linear, free termini)
+1 sequence-only estimate (linear, free termini)
0.75 sequence-only estimate (linear, free termini)
-0.244 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against over 120 strains of L. lactis subsp. cremoris, L. lactis subsp. lactis and L. lactis subsp. cremoris. Senstitivity depends on bacterial strains. Sensitive strains are rapidly killed by this bacteriocin. e.g., highly sensitive: L. lactis subsp. cremoris IMN C18 (5 Bu/ml), NCDO 607 (1.3 Bu/ml), NCDO 1198 (0.5 Bu/ml), L. lactis subsp. lactis IL 1403 (0.4 BU/ml), Not sensitive: L.raffinolactis NCDO 617 (sensitivity >10,000 BU/ml), L.lactis subsp. cremoris LMG 2130 (sensitivity >10,000 BU/ml), and L.lactis subsp. lactis NIZO 4-25 (biovar diacetylactis) (sensitivity >10,000 BU/ml).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against over 120 strains of L. lactis subsp. cremoris, L. lactis subsp. lactis and L. lactis subsp. cremoris. Senstitivity depends on bacterial strains. Sensitive strains are rapidly killed by this bacteriocin. e.g., highly sensitive: L. lactis subsp. cremoris IMN C18 (5 Bu/ml), NCDO 607 (1.3 Bu/ml), NCDO 1198 (0.5 Bu/ml), L. lactis subsp. lactis IL 1403 (0.4 BU/ml), Not sensitive: L.raffinolactis NCDO 617 (sensitivity >10,000 BU/ml), L.lactis subsp. cremoris LMG 2130 (sensitivity >10,000 BU/ml), and L.lactis subsp. lactis NIZO 4-25 (biovar diacetylactis) (sensitivity >10,000 BU/ml).
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

DRAMP

Other

Active against over 120 strains of L. lactis subsp. cremoris, L. lactis subsp. lactis and L. lactis subsp. cremoris. Senstitivity depends on bacterial strains. Sensitive strains are rapidly killed by this bacteriocin. e.g., highly sensitive: L. lactis subsp. cremoris IMN C18 (5 Bu/ml), NCDO 607 (1.3 Bu/ml), NCDO 1198 (0.5 Bu/ml), L. lactis subsp. lactis IL 1403 (0.4 BU/ml), Not sensitive: L.raffinolactis NCDO 617 (sensitivity >10,000 BU/ml), L.lactis subsp. cremoris LMG 2130 (sensitivity >10,000 BU/ml), and L.lactis subsp. lactis NIZO 4-25 (biovar diacetylactis) (sensitivity >10,000 BU/ml).