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Peptide record

TPDB14500

Antibacterial Anticancer Antifungal Antiparasitic Neurotoxin Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB14500
Antibacterial Anticancer Antifungal Antiparasitic Neurotoxin Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb NTxPred2 ToxinPred 3.0
standard
No
A 26-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
KIKWFKTMKSLAKFLAKEQMKKHLGE
Physicochemical Analysis
C147H242N38O34S2
RNDCPYV
K
3149.89
10.74
9
2
11
+6
6.88
-0.723
67.69
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
174.61
3
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
2
E
1
Q
1
G
1
H
1
I
3
L
8
K
2
M
2
F
0
P
1
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 2 Q: 1 G: 1 H: 1 I: 1 L: 3 K: 8 M: 2 F: 2 P: 0 S: 1 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
26
C147H242N38O34S2
3149.89
10.74
+6
6.88
-0.723
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Forms pore that permeabilize the cell membrane. Promotes efflux of calcium from synaptosomes, causes hemolysis, and dissipates voltage gradients across muscle membrane. Potently inhibits the growth of bacteria and yeast. May function both in the prey capture strategy as well as protection from infectious organisms arising from prey ingestion (By similarity). {ECO:0000250}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Lycosa singoriensis (Wolf spider) (Aranea singoriensis)
Neurotoxin
Forms pore that permeabilize the cell membrane. Promotes efflux of calcium from synaptosomes, causes hemolysis, and dissipates voltage gradients across muscle membrane.
M-lycotoxin-Ls2a (M-LCTX-Ls2a) (Lycocitin-3)
spider
Cationic peptide 04 (cupiennin) family, 05 subfamily
Evidence at protein level
Antibiotic Antimicrobial Cytolysis Direct protein sequencing Hemolysis Ion transport Membrane Neurotoxin Secreted Target cell membrane Target membrane Toxin Transmembrane Transport
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Antibiotic Antimicrobial Cytolysis Direct protein sequencing Hemolysis Ion transport Membrane Neurotoxin Secreted Target cell membrane Target membrane Toxin Transmembrane Transport
Neurotoxin
Evidence at protein level
Cationic peptide 04 (cupiennin) family, 05 subfamily
M-lycotoxin-Ls2a (M-LCTX-Ls2a) (Lycocitin-3)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider