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Peptide record

TPDB14483

Antibacterial Antifungal Toxicity standard
108 amino acids
Basic Information
3D PDB MODEL
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TPDB14483
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia Antifungipept
standard
No
A 108-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, and Antifungipept, with an available 3D structural model.
Sequence
KFKWGKLFSTAKKLYKKGKKLSKNKNFKKALKFGKQLAKNLQAGEEHEPGTPVGNNKCWAIGTTCSDDCDCCPEHHCHCPAGKWLPGLFRCTCQVTESDKVNKCPPAE
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C531H837N151O149S10
M
K
12041.01
9.36
25
10
28
+11
1.79
-0.823
47.04
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
18615
1.55
30
Residue Composition
number
7
A
1
R
6
N
4
D
10
C
6
E
3
Q
9
G
4
H
1
I
8
L
20
K
0
M
5
F
7
P
4
S
6
T
3
W
1
Y
3
V
Amino Acid Distribution
A: 7 R: 1 N: 6 D: 4 C: 10 E: 6 Q: 3 G: 9 H: 4 I: 1 L: 8 K: 20 M: 0 F: 5 P: 7 S: 4 T: 6 W: 3 Y: 1 V: 3
Chemical Descriptors
108 reviewed residue count
C531H837N151O149S10 sequence-only estimate (linear, free termini)
12041.01 sequence-only estimate (linear, free termini)
9.36 sequence-only estimate (linear, free termini)
+11 sequence-only estimate (linear, free termini)
1.79 sequence-only estimate (linear, free termini)
-0.823 sequence-only estimate (linear, free termini)
Evidence Records 8 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.6-1.25 µM

Target

A. globiformis VKM Ac-1112

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Full length and N-terminal domain are active against A. globiformis VKM Ac-1112 (MIC 0.6-1.25 uM), B. subtilis VKM B-501 (0.12-0.25 uM), and E. coli DH5alpha (MIC 0.12-0.25 uM). The full
Evidence 2 Activity

Activity

MIC
Antibacterial
0.12-0.25 µM

Target

Escherichia coli DH5alpha

Source & Reference

dbAMP

Other

t A. globiformis VKM Ac-1112 (MIC 0.6-1.25 uM), B. subtilis VKM B-501 (0.12-0.25 uM), and E. coli DH5alpha (MIC 0.12-0.25 uM). The full length is not as active as the N-terminal domain (OtTx1a-AMP) in inhibiting P.
Evidence 3 Activity

Activity

MIC
Antibacterial
5-10 µM

Target

Enterococcus faecalis VKM B-871

Source & Reference

dbAMP

Other

x1a-AMP) in inhibiting P. aeruginosa PAO1. In addition, OtTx1a-AMP is also active against E. faecalis VKM B-871 (MIC 5-10 uM), and S. aureus 209P (MIC 0.6-1.25 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
0.6-1.25 µM

Target

Staphylococcus aureus 209P

Source & Reference

dbAMP

Other

. In addition, OtTx1a-AMP is also active against E. faecalis VKM B-871 (MIC 5-10 uM), and S. aureus 209P (MIC 0.6-1.25 uM).
Evidence 5 Activity

Activity

MIC
Antifungal
0.6-1.25 µM

Target

A. globiformis VKM Ac-1112

Source & Reference

dbAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Full length and N-terminal domain are active against A. globiformis VKM Ac-1112 (MIC 0.6-1.25 uM), B. subtilis VKM B-501 (0.12-0.25 uM), and E. coli DH5alpha (MIC 0.12-0.25 uM). The full
Evidence 6 Activity

Activity

MIC
Antifungal
0.12-0.25 µM

Target

Escherichia coli DH5alpha

Source & Reference

dbAMP Antifungipept

Other

t A. globiformis VKM Ac-1112 (MIC 0.6-1.25 uM), B. subtilis VKM B-501 (0.12-0.25 uM), and E. coli DH5alpha (MIC 0.12-0.25 uM). The full length is not as active as the N-terminal domain (OtTx1a-AMP) in inhibiting P.
Evidence 7 Activity

Activity

MIC
Antifungal
5-10 µM

Target

Enterococcus faecalis VKM B-871

Source & Reference

dbAMP Antifungipept

Other

x1a-AMP) in inhibiting P. aeruginosa PAO1. In addition, OtTx1a-AMP is also active against E. faecalis VKM B-871 (MIC 5-10 uM), and S. aureus 209P (MIC 0.6-1.25 uM).
Evidence 8 Activity

Activity

MIC
Antifungal
0.6-1.25 µM

Target

Staphylococcus aureus 209P

Source & Reference

dbAMP Antifungipept

Other

. In addition, OtTx1a-AMP is also active against E. faecalis VKM B-871 (MIC 5-10 uM), and S. aureus 209P (MIC 0.6-1.25 uM).