Back to search

Peptide record

TPDB14475

Antibacterial Antifungal Toxicity standard
64 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB14475
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP DRAMP Peptipedia Antifungipept
standard
No
A 64-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
KDGYLVGNDGCKYSCFTRPGTYCANECSRVKGKDGYCYAWMACYCYSMPNWVKTWNRATNRCGR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C318H470N92O92S10
QHI
C
7374.39
8.69
10
4
21
+6
2.10
-0.723
25.94
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
27430
3.72
27
Residue Composition
number
4
A
5
R
5
N
3
D
8
C
1
E
0
Q
7
G
0
H
0
I
1
L
5
K
2
M
1
F
2
P
3
S
4
T
3
W
7
Y
3
V
Amino Acid Distribution
A: 4 R: 5 N: 5 D: 3 C: 8 E: 1 Q: 0 G: 7 H: 0 I: 0 L: 1 K: 5 M: 2 F: 1 P: 2 S: 3 T: 4 W: 3 Y: 7 V: 3
Chemical Descriptors
64 reviewed residue count
C318H470N92O92S10 sequence-only estimate (linear, free termini)
7374.39 sequence-only estimate (linear, free termini)
8.69 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
2.10 sequence-only estimate (linear, free termini)
-0.723 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

8% Hemolysis
Toxicity
90 µM
Hemolytic Cytotoxic
8% Hemolysis | 90 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibacterial activity of six novel peptides from Tityus discrepans scorpion venom. A fluorescent probe study of microbial membrane Na+ permeability changes. | Toxicon | 2009
Evidence 2 Activity

Activity

21% Hemolysis
Toxicity
180 µM
Hemolytic Cytotoxic
21% Hemolysis | 180 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibacterial activity of six novel peptides from Tityus discrepans scorpion venom. A fluorescent probe study of microbial membrane Na+ permeability changes. | Toxicon | 2009