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Peptide record

TPDB14474

Antibacterial Antifungal Toxicity standard
61 amino acids
Basic Information
3D PDB MODEL
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TPDB14474
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP DRAMP Peptipedia Antifp Antifungipept
standard
No
A 61-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
KDGYIIEHRGCKYSCFFGTNSWCNTECTLKKGSSGYCAWPACWCYGLPDNVKIFDSNNLKC
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C306H448N80O89S8
QM
C
6927.89
7.84
8
5
19
+2
1.35
-0.403
46.39
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
22960
3.31
25
Residue Composition
number
2
A
1
R
5
N
3
D
8
C
2
E
0
Q
6
G
1
H
3
I
3
L
6
K
0
M
3
F
2
P
5
S
3
T
3
W
4
Y
1
V
Amino Acid Distribution
A: 2 R: 1 N: 5 D: 3 C: 8 E: 2 Q: 0 G: 6 H: 1 I: 3 L: 3 K: 6 M: 0 F: 3 P: 2 S: 5 T: 3 W: 3 Y: 4 V: 1
Chemical Descriptors
61 reviewed residue count
C306H448N80O89S8 sequence-only estimate (linear, free termini)
6927.89 sequence-only estimate (linear, free termini)
7.84 sequence-only estimate (linear, free termini)
+2 sequence-only estimate (linear, free termini)
1.35 sequence-only estimate (linear, free termini)
-0.403 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
90 µM
Hemolytic Cytotoxic
0% Hemolysis | 90 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibacterial activity of six novel peptides from Tityus discrepans scorpion venom. A fluorescent probe study of microbial membrane Na+ permeability changes. | Toxicon | 2009
Evidence 2 Activity

Activity

1% Hemolysis
Toxicity
180 µM
Hemolytic Cytotoxic
1% Hemolysis | 180 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibacterial activity of six novel peptides from Tityus discrepans scorpion venom. A fluorescent probe study of microbial membrane Na+ permeability changes. | Toxicon | 2009