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Peptide record

TPDB14473

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
69 amino acids
Basic Information
3D PDB MODEL
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TPDB14473
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
dbAMP DRAMP Peptipedia Antifungipept APD_complete HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 69-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
KAVAAKKSPKKAKKPATPKKAAKSPKKVKKPAAAAKKAAKSPKKATKAAKPKAAKPKAAKAKKAAPKKK
Physicochemical Analysis
C321H587N99O75
RNDCEQGHILMFWY
K
7033.81
11.96
30
0
25
+30
30.65
-1.238
41.74
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
5
Residue Composition
number
23
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
30
K
0
M
0
F
9
P
3
S
2
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 23 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 30 M: 0 F: 0 P: 9 S: 3 T: 2 W: 0 Y: 0 V: 2
Chemical Descriptors
69
C321H587N99O75
7033.81
11.96
+30
30.65
-1.238
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.8 µM

Target

P. citreus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against M. luteus (MIC ~1.0 uM), P. citreus (MIC 0.8 uM), E. coli (MIC ~1 uM), and L. anguillarum (MIC ~ 1 uM). It had an effect on lipid bilayer
Evidence 2 Activity

Activity

MIC
Antifungal
0.8 µM

Target

P. citreus

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against M. luteus (MIC ~1.0 uM), P. citreus (MIC 0.8 uM), E. coli (MIC ~1 uM), and L. anguillarum (MIC ~ 1 uM). It had an effect on lipid bilayer
Evidence 3 Activity

Activity

MIC
Antiparasitic
0.8 µM

Target

P. citreus

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against M. luteus (MIC ~1.0 uM), P. citreus (MIC 0.8 uM), E. coli (MIC ~1 uM), and L. anguillarum (MIC ~ 1 uM). It had an effect on lipid bilayer
Evidence 4 Activity

Activity

7% Hemolysis
Toxicity
0.8 µM
Hemolytic Cytotoxic
7% Hemolysis | 0.8 | µM | target cell: Trout erythrocytes

Target

Trout erythrocytes

Source & Reference

NA
DBAASP
Isolation and characterisation of oncorhyncin II, a histone H1-derived antimicrobial peptide from skin secretions of rainbow trout, Oncorhynchus mykiss. | Dev Comp Immunol | 2004
Evidence 5 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.