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Peptide record

TPDB14388

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
76 amino acids
Basic Information
3D PDB MODEL
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TPDB14388
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
dbAMP DRAMP Peptipedia AFP-GFuse Antifp Antifungipept APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 76-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GWMSEKKVQGILDKKLPEGIIRNAAKAIVHKMAKNQFGCFANVDVKGDCKRHCKAEDKEGICHGTKCKCGVPISYL
Physicochemical Analysis
C365H599N107O102S8
K
8374.91
9.40
18
8
26
+7
23.01
-0.409
73.16
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7365
87.94
15
Residue Composition
number
6
A
2
R
3
N
4
D
6
C
4
E
2
Q
8
G
3
H
6
I
3
L
13
K
2
M
2
F
2
P
2
S
1
T
1
W
1
Y
5
V
Amino Acid Distribution
A: 6 R: 2 N: 3 D: 4 C: 6 E: 4 Q: 2 G: 8 H: 3 I: 6 L: 3 K: 13 M: 2 F: 2 P: 2 S: 2 T: 1 W: 1 Y: 1 V: 5
Chemical Descriptors
76
C365H599N107O102S8
8374.91
9.40
+7
23.01
-0.409
Evidence Records 4 records
Evidence 1 Activity

Activity

Hemolysis
[Swiss_Prot Entry Q0GY40]has hemolytic activity

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Cell Mol Life Sci. 2008 Jan 65(1):187-200.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

100% Hemolysis
Toxicity
0.2 µM
Hemolytic Cytotoxic
100% Hemolysis | 0.2 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cytolytic and K+ channel blocking activities of beta-KTx and scorpine-like peptides purified from scorpion venoms. | Cell Mol Life Sci | 2008
Evidence 3 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Swiss_Prot Entry Q0GY40]has hemolytic activity

Target

erythrocytes

Source & Reference

NA
DRAMP
Cell Mol Life Sci. 2008 Jan 65(1):187-200.
Evidence 4 Hemolysis

Activity

[Swiss_Prot Entry Q0GY40]has hemolytic activity
Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
Cell Mol Life Sci. 2008 Jan 65(1):187-200.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.